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567616 Sodium 4-Phenylbutyrate - CAS 1716-12-7 - Calbiochem

Sodium 4-Phenylbutyrate, CAS 1716-12-7, is a novel anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation.

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Synonymes: SPB, PBNa, 4PBA, 4-Phenylbutyrate, Na, BCKD Kinase Inhibitor I, Branched-Chain α-Ketoacid Dehydrogenase Kinase Inhibitor I, BDK Inhibitor I

Primary Target: Anti-neoplastic agent
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567616
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Tableau de caractéristiques principal

CAS #Empirical Formula
1716-12-7C₁₀H₁₁O₂Na

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      Description
      OverviewA novel anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation. Increases fetal hemoglobin production in vitro and in vivo.
      Catalogue Number567616
      Brand Family Calbiochem®
      SynonymsSPB, PBNa, 4PBA, 4-Phenylbutyrate, Na, BCKD Kinase Inhibitor I, Branched-Chain α-Ketoacid Dehydrogenase Kinase Inhibitor I, BDK Inhibitor I
      References
      ReferencesTso, S.C., et al. 2013. Proc. Natl. Acad. Sci. USA 110, 9728.
      Ozcan, U., et al. 2006. Science 313, 1137.
      Carducci, M.A., et al. 2001. Clin. Cancer Res. 7, 3047.
      Rubenstein, R.C. and Zeitlin, P.L. 2000. Am.J. Physiol. Cell. Physiol. 278, C259.
      Lea, M.A., et al. 1999. Anticancer Res. 19, 1971.
      Miller, A.C., et al. 1997. Int. J. Radiat. Biol. 72, 211.
      Rubenstein, R.C., et al. 1997. J. Clin. Invest. 100, 2457.
      Pineau, T., et al. 1996. Biochem. Pharmacol. 52, 659.
      Collins, A.F., et al. 1995. Blood 85, 43.
      Lea, M.A., et al. 1995. Anticancer Res. 15, 879.
      Figg, W.D., et al. 1994. Anticancer Drugs 5, 336.
      Liu, L., et al. 1994. J. Invest. Dermatol. 103, 335.
      Product Information
      CAS number1716-12-7
      ATP CompetitiveN
      FormWhite to slightly yellow solid
      Hill FormulaC₁₀H₁₁O₂Na
      Chemical formulaC₁₀H₁₁O₂Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationSodium 4-Phenylbutyrate, CAS 1716-12-7, is a novel anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation.
      Biological Information
      Primary TargetAnti-neoplastic agent
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Référence GTIN
      567616-100MG 04055977266818