566660 Sigma-AldrichSmoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem
A cell-permeable Smoothened Agonist, SAG, CAS 364590-63-6, modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM).
More>> A cell-permeable Smoothened Agonist, SAG, CAS 364590-63-6, modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Less<<FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: N-Methyl-Nʹ-(3-pyridinylbenzyl)-Nʹ-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane, SAG1.3
Produits recommandés
Aperçu
| Replacement Information |
|---|
Tableau de caractéristiques principal
| CAS # | Empirical Formula |
|---|---|
| 364590-63-6 | C₂₈H₂₈ClN₃OS • 2HCl • 2H₂O |
Prix & Disponibilité
| Référence | Disponibilité | Conditionnement | Qté | Prix | Quantité | |
|---|---|---|---|---|---|---|
| 566660-1MG |
|
Flacon en verre | 1 mg |
|
— | |
| 566660-5MG |
|
Flacon en verre | 5 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Shown to induce Smo internalization. Shown to induce Hedgehog pathway activation (EC50 = ∼ 3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine-KAAD (Cat. No. 239804) inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations. A 10 mM (500 µg/86 µl) solution of Smoothened Agonist, SAG (Cat. No. 566661) in H2O is also available. |
| Catalogue Number | 566660 |
| Brand Family | Calbiochem® |
| Synonyms | N-Methyl-Nʹ-(3-pyridinylbenzyl)-Nʹ-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane, SAG1.3 |
| Product Information | |
|---|---|
| CAS number | 364590-63-6 |
| Form | Light yellow solid |
| Hill Formula | C₂₈H₂₈ClN₃OS • 2HCl • 2H₂O |
| Chemical formula | C₂₈H₂₈ClN₃OS • 2HCl • 2H₂O |
| Hygroscopic | Hygroscopic |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
|---|
| Biological Information | |
|---|---|
| Purity | ≥98% by HPLC |
| Physicochemical Information |
|---|
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Référence | GTIN |
| 566660-1MG | 07790788051570 |
| 566660-5MG | 04055977191578 |
Documentation
Smoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem FDS
| Titre |
|---|
Smoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem Certificats d'analyse
| Titre | Numéro de lot |
|---|---|
| 566660 |
Références bibliographiques
| Aperçu de la référence bibliographique |
|---|
| Wang, J., et al. 2010. Proc. Natl. Acad. Sci. USA. 107, 9323. Meloni, A.R., et al. 2006. Mol. Cell. Biol. 26, 7750. Chen, W., et al. 2004. Science 306, 2257. Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071. Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10. |
Citations
| Titre | |
|---|---|
|
|
| Fiche technique | ||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
|