566224 Sigma-AldrichSialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac - Calbiochem
Sialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac, is a cell-permeable sialylic acid analog that is converted to a CMP-Neu5Ac and inhibits sialyltransferase.
More>> Sialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac, is a cell-permeable sialylic acid analog that is converted to a CMP-Neu5Ac and inhibits sialyltransferase. Less<<FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: (1S,2R)-1-((3S,4R,5R,6S)-3-acetamido-4,6-diacetoxy-5-fluoro-6-(methoxycarbonyl)tetrahydro-2H-pyran-2-yl)propane-1,2,3-triyl triacetate, 3Fax-Neu5Ac Prodrug
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Aperçu
Tableau de caractéristiques principal
| Empirical Formula |
|---|
| C₂₂H₃₀FNO₁₄ |
Prix & Disponibilité
| Référence | Disponibilité | Conditionnement | Qté | Prix | Quantité | |
|---|---|---|---|---|---|---|
| 566224-10MG |
|
Flacon en verre | 10 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable sialylic acid analog that upon cellular uptake is transformed into a CMP-Neu5Ac (Cat. No. 233264) mimetic bearing a C3 fluorine substituent at the axial position, effectively inhibiting sialyltransferase in a donor substrate CMP-Neu5Ac-competitive manner. Shown to effectively abloishes HL-60 cell surface SLeX expression (by >95%; 200 µM for 5 days), resulting in dramatic reductions in cell surface E-selectin and P-selectin binding (by >95% and >80%, respectively), without affecting cell viability or proliferation. |
| Catalogue Number | 566224 |
| Brand Family | Calbiochem® |
| Synonyms | (1S,2R)-1-((3S,4R,5R,6S)-3-acetamido-4,6-diacetoxy-5-fluoro-6-(methoxycarbonyl)tetrahydro-2H-pyran-2-yl)propane-1,2,3-triyl triacetate, 3Fax-Neu5Ac Prodrug |
| References | |
|---|---|
| References | Rillahan, C., et al. 2012. Nat. Chem. Bio. 8, 661. |
| Product Information | |
|---|---|
| Form | White solid |
| Hill Formula | C₂₂H₃₀FNO₁₄ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Sialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac, is a cell-permeable sialylic acid analog that is converted to a CMP-Neu5Ac and inhibits sialyltransferase. |
| Biological Information | |
|---|---|
| Primary Target | Sialyltransferase |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Référence | GTIN |
| 566224-10MG | 04055977191332 |