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572635 SU6656 - CAS 330161-87-0 - Calbiochem

SU6656, CAS 330161-87-0, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of Src (IC50 = 280 nM). Also inhibits Fyn (IC50 = 170 nM), Yes (IC50 = 20 nM), and Lyn (IC50 = 130 nM).

SU6656 - CAS 330161-87-0 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Primary Target: Src
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572635
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Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
330161-87-0C₁₉H₂₁N₃O₃S

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572635-1MG
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      Description
      OverviewA potent, cell-permeable, reversible, and ATP-competitive Src family kinase inhibitor. Inhibits Src (IC50 = 280 nM) as well as closely related kinases such as Fyn (IC50 = 170 nM) and Yes (IC50 = 20 nM) and Lyn (IC50 = 130 nM). Acts as a weak inhibitor of Lck (IC50 = 688 µM) and PDGF receptor kinase (IC50 >10 µM). A 10 mM (500 µg/135 µl) solution of SU6656 (Cat. No. 572636) in DMSO is also available.
      Catalogue Number572635
      Brand Family Calbiochem®
      References
      ReferencesBowman, T., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 7319.
      Blake, R.A., et al. 2000. Mol. Cell. Biol. 20, 9018.
      Product Information
      CAS number330161-87-0
      ATP CompetitiveY
      FormBurnt orange solid
      Hill FormulaC₁₉H₂₁N₃O₃S
      Chemical formulaC₁₉H₂₁N₃O₃S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationSU6656, CAS 330161-87-0, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of Src (IC50 = 280 nM). Also inhibits Fyn (IC50 = 170 nM), Yes (IC50 = 20 nM), and Lyn (IC50 = 130 nM).
      Biological Information
      Primary TargetSrc
      Primary Target IC<sub>50</sub>280 nM, 170 nM, 20 nM, and 130 nM against Src, Fyn, Yes, and Lyn.
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      572635-1MG 04055977266290

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      SU6656 - CAS 330161-87-0 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      SU6656 - CAS 330161-87-0 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      572635

      Références bibliographiques

      Aperçu de la référence bibliographique
      Bowman, T., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 7319.
      Blake, R.A., et al. 2000. Mol. Cell. Biol. 20, 9018.

      Citations

      Titre
    • Malcolm A. Meyn, et al. (2005) Src family kinase activity is required for murine embryonic stem cell growth and differentiation. Molecular Pharmacology 68, 1320-1330.
      		•
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-March-2010 JSW
      DescriptionA potent, cell-permeable, reversible, and ATP-competitive inhibitor of Src-family protein tyrosine kinases. Inhibits Src (IC50 = 280 nM) as well as closely related kinases Fyn (IC50 = 170 nM), Yes (IC50 = 20 nM) and Lyn (IC50 = 130 nM). The inhibition is competitive with respect to ATP. Has only a trivial effect on Lck (IC50 = 6.88 µM). Does not affect the activity of PDGF-β receptor kinase (IC50 ≥10 µM) and IGF-1 receptor kinase (IC50 ≥20 µM).
      FormBurnt orange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number330161-87-0
      Chemical formulaC₁₉H₂₁N₃O₃S
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBowman, T., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 7319.
      Blake, R.A., et al. 2000. Mol. Cell. Biol. 20, 9018.
      Citation
    • Malcolm A. Meyn, et al. (2005) Src family kinase activity is required for murine embryonic stem cell growth and differentiation. Molecular Pharmacology 68, 1320-1330.
      		•