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509708 SKF-97541 - CAS 127729-35-5 - Calbiochem

A highly potent agonist of GABAB receptor. Shown to be about 10-times more potent than baclofen.

SKF-97541 - CAS 127729-35-5 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: GABAB Receptor Agonist, SKF-97541, SKF 97541, CGP 35024, 3-APMPA

Primary Target: GABAB
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509708
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Tableau de caractéristiques principal

CAS #Empirical Formula
127729-35-5C₄H₁₂NO₂P

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      Description
      OverviewA highly potent agonist of GABAB receptor. Depresses excitatory postsynaptic potentials mediated by glutamate in the striatum, and hyperpolarized neurones in the substantia nigra (IC50 = 92 nM). Shown to be about 10-times more potent than baclofen (Cat. No. 505873). Induces vasodepression in pulmonary vascular bed that is modulated by an ATP-sensitive K+ channel. Induces gastric acid secretion in a dose-dependent manner (0.01 - 3 mg/kg, i.v.) in mice.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number509708
      Brand Family Calbiochem®
      SynonymsGABAB Receptor Agonist, SKF-97541, SKF 97541, CGP 35024, 3-APMPA
      References
      ReferencesKaye, A.D., et al. 2004. Anesth. Analg. 99, 758.
      Piqueras, L., and Martinez, V. 2004. Br. J. Pharmacol. 142, 1038.
      Seabrook, G.R., et al. 1990. Br. J. Pharmacol. 101, 949.
      Product Information
      CAS number127729-35-5
      FormWhite solid
      Hill FormulaC₄H₁₂NO₂P
      Chemical formulaC₄H₁₂NO₂P
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGABAB
      Purity≥98% by TLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      5.09708.0001 04055977241082

      Documentation

      SKF-97541 - CAS 127729-35-5 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Kaye, A.D., et al. 2004. Anesth. Analg. 99, 758.
      Piqueras, L., and Martinez, V. 2004. Br. J. Pharmacol. 142, 1038.
      Seabrook, G.R., et al. 1990. Br. J. Pharmacol. 101, 949.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-February-2014 JSW
      SynonymsGABAB Receptor Agonist, SKF-97541, SKF 97541, CGP 35024, 3-APMPA
      DescriptionA highly potent agonist of GABAB receptor. Depresses excitatory postsynaptic potentials mediated by glutamate in the striatum, and hyperpolarized neurones in the substantia nigra (IC50 = 92 nM). Shown to be about 10-times more potent than baclofen (Cat. No. 505873). Induces vasodepression in pulmonary vascular bed that is modulated by an ATP-sensitive K+ channel. Induces gastric acid secretion in a dose-dependent manner (0.01 - 3 mg/kg, i.v.) in mice.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number127729-35-5
      Chemical formulaC₄H₁₂NO₂P
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityH₂O (100 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKaye, A.D., et al. 2004. Anesth. Analg. 99, 758.
      Piqueras, L., and Martinez, V. 2004. Br. J. Pharmacol. 142, 1038.
      Seabrook, G.R., et al. 1990. Br. J. Pharmacol. 101, 949.