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505723 SCH 23390 Hydrochloride - CAS 125941-87-9 - Calbiochem

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Synonymes: Dopamine Receptor D1/D5 Antagonist, SCH 23390, (R)-(+)-7-Chloro-8-hydroxy-3-methyl­-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine Hydrochloride, SCH23390, SCH-23390

Primary Target: D1 and D5
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      125941-87-9C₁₇H₁₈ClNO•HCl
      Description
      OverviewA highly potent and selective dopamine D1-like receptor antagonist with a Ki of 0.2 and 0.3 nM for the D1 and D5 dopamine receptor subtypes, respectively. Also an agonist at 5-HT1C and 5-HT2C receptors in vitro (Ki values are 6.3 nM and 9.3 nM respectively).
      Catalogue Number505723
      Brand Family Calbiochem®
      SynonymsDopamine Receptor D1/D5 Antagonist, SCH 23390, (R)-(+)-7-Chloro-8-hydroxy-3-methyl­-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine Hydrochloride, SCH23390, SCH-23390
      References
      ReferencesSplinter, M. Y. 2007. Ann. Pharmacother. 41, 285.
      Pfeiffer, R. F. 2002. Drugs Aging. 19, 561.
      Product Information
      CAS number125941-87-9
      FormOff-white solid
      Hill FormulaC₁₇H₁₈ClNO•HCl
      Chemical formulaC₁₇H₁₈ClNO•HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetD1 and D5
      Primary Target K<sub>i</sub>0.2 nM
      Purity≥99% by Chiral HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      505723 0

      Documentation

      SCH 23390 Hydrochloride - CAS 125941-87-9 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Splinter, M. Y. 2007. Ann. Pharmacother. 41, 285.
      Pfeiffer, R. F. 2002. Drugs Aging. 19, 561.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-August-2013 JSW
      SynonymsDopamine Receptor D1/D5 Antagonist, SCH 23390, (R)-(+)-7-Chloro-8-hydroxy-3-methyl­-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine Hydrochloride, SCH23390, SCH-23390
      DescriptionA highly potent and selective dopamine D1-like receptor antagonist with a Ki of 0.2 and 0.3 nM for the D1 and D5 dopamine receptor subtypes, respectively. Also an agonist at 5-HT1C and 5-HT2C receptors in vitro (Ki values are 6.3 nM and 9.3 nM respectively).
      FormOff-white solid
      CAS number125941-87-9
      Chemical formulaC₁₇H₁₈ClNO•HCl
      Structure formulaStructure formula
      Purity≥99% by Chiral HPLC
      SolubilityH₂O (100 mM)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSplinter, M. Y. 2007. Ann. Pharmacother. 41, 285.
      Pfeiffer, R. F. 2002. Drugs Aging. 19, 561.