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559418 SBHA - CAS 38937-66-5 - Calbiochem

A cell-permeable bishydroxamic acid histone deacetylase (HDAC) inhibitor with anti-tumor properties.

SBHA - CAS 38937-66-5 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Suberic Bishydroxamate, Suberoyl Bishydroxamic Acid, HDAC Inhibitor XII

Primary Target: human HDAC1 and HDAC3 activities
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559418
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Tableau de caractéristiques principal

CAS #Empirical Formula
38937-66-5C₈H₁₆N₂O₄

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559418-100MG
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      Description
      OverviewA cell-permeable bishydroxamic acid histone deacetylase (HDAC) inhibitor with anti-tumor properties. Causes an increase in acetylated histone H4 in MEL cells and inhibits the human HDAC1 and HDAC3 activities with a similar potency (ID50 ~ 250-300 nM). Belongs to the hybrid polar class of compounds that acts both as inducers of differentiation of transformed cells and apoptosis. Suppresses the growth of proliferating keratinocytes and squamous cell carcinoma cells (IC50 = 11.57 µM and 5.39 µM, respectively).
      Catalogue Number559418
      Brand Family Calbiochem®
      SynonymsSuberic Bishydroxamate, Suberoyl Bishydroxamic Acid, HDAC Inhibitor XII
      References
      ReferencesBrinkmann, H., et al. 2001. J. Biol. Chem. 276, 22491.
      Richon, V.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 3003.
      Richon, V.M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 5705.
      Marks, P.A., 1994. Proc. Natl. Acad. Sci. USA 91, 10251.
      Product Information
      CAS number38937-66-5
      ATP CompetitiveN
      DeclarationNot available for sale in the United States.
      FormWhite solid
      Hill FormulaC₈H₁₆N₂O₄
      Chemical formulaC₈H₁₆N₂O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targethuman HDAC1 and HDAC3 activities
      Primary Target IC<sub>50</sub>11.57 µM and 5.39 µM in suppressing the growth of proliferating keratinocytes and squamous cell carcinoma cells, respectively
      Purity≥95% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.


      From Catalog:
      Desc. Field- added "cell-permeable
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      559418-100MG 04055977268171

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      SBHA - CAS 38937-66-5 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      SBHA - CAS 38937-66-5 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      559418

      Références bibliographiques

      Aperçu de la référence bibliographique
      Brinkmann, H., et al. 2001. J. Biol. Chem. 276, 22491.
      Richon, V.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 3003.
      Richon, V.M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 5705.
      Marks, P.A., 1994. Proc. Natl. Acad. Sci. USA 91, 10251.

      Informations techniques

      Titre
      White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-September-2021 JSW
      SynonymsSuberic Bishydroxamate, Suberoyl Bishydroxamic Acid, HDAC Inhibitor XII
      DescriptionA cell-permeable bishydroxamic acid histone deacetylase (HDAC) inhibitor with anti-tumor properties. Reported to cause an increase in acetylated histone H4 in MEL cells. Also reported to inhibit human HDAC1 and HDAC3 activities with a similar potency (ID50 ~ 250-300 nM). Belongs to the hybrid polar class of compounds that induce both differentiation of transformed cells and apoptosis. Shown to suppress the growth of proliferating keratinocytes and squamous cell carcinoma cells (IC50 = 11.57 µM and 5.39 µM, respectively).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number38937-66-5
      Chemical formulaC₈H₁₆N₂O₄
      Structure formulaStructure formula
      Purity≥95% by TLC
      SolubilityDMSO (10 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.


      From Catalog:
      Desc. Field- added "cell-permeable
      Toxicity Standard Handling
      ReferencesBrinkmann, H., et al. 2001. J. Biol. Chem. 276, 22491.
      Richon, V.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 3003.
      Richon, V.M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 5705.
      Marks, P.A., 1994. Proc. Natl. Acad. Sci. USA 91, 10251.