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559303 SANT-1 - CAS 304909-07-7 - Calbiochem

A potent, cell-permeable antagonist of the Shh signaling pathway by binding directly to Smoothened, a distant relative of G protein-coupled receptors.

SANT-1 - CAS 304909-07-7 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Shh Signaling Antagonist V

Primary Target: Shh (Sonic Hedgehog) signaling pathway
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559303
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Tableau de caractéristiques principal

CAS #Empirical Formula
304909-07-7C₂₃H₂₇N₅

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      Description
      OverviewA potent, cell-permeable antagonist of the Shh (Sonic Hedgehog) signaling pathway (IC50 = 20 nM in the Shh-LIGHT2 assay and in Ptch1-l- cells) by binding directly to Smoothened (Smo; Kd = 1.2 nM), a distant relative of G protein-coupled receptors. Unlike cyclopamine (Cat. No. 239803), SANT-1 equipotently inhibits the activities of both wild-type and oncogenic Smo (IC50 = 30 nM in SmoA1-LIGHT2 assay).
      Catalogue Number559303
      Brand Family Calbiochem®
      SynonymsShh Signaling Antagonist V
      References
      ReferencesChen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
      Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
      Product Information
      CAS number304909-07-7
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₃H₂₇N₅
      Chemical formulaC₂₃H₂₇N₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetShh (Sonic Hedgehog) signaling pathway
      Primary Target IC<sub>50</sub>20 nM as antagonist of the Shh (Sonic Hedgehog) signaling pathway in the Shh-LIGHT2 assay and in Ptch1-l- cells
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.



      From Catalog:
      Desc. Field- added "cell-permeable
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      559303-5MG 04055977192414

      Documentation

      SANT-1 - CAS 304909-07-7 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      SANT-1 - CAS 304909-07-7 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      559303

      Références bibliographiques

      Aperçu de la référence bibliographique
      Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
      Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.

      Brochure

      Titre
      Stem Cell Resource Brochure GBP
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-October-2007 JSW
      SynonymsShh Signaling Antagonist V
      DescriptionA potent antagonist of the Sonic Hedgehog (Shh) signaling pathway (IC50 = 20 nM in Shh-LIGHT2 assay and in Ptch1-l-< cells) that acts by binding to Smoothened (Smo; KD = 1.2 nM), a distant relative of G protein-coupled receptors. In contrast to cyclopamine, SANT-1 inhibits the activities of both wild type and oncogenic Smo with equal potency (IC50 = 30 nM in SmoA1-LIGHT2 assay).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number304909-07-7
      Chemical formulaC₂₃H₂₇N₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.



      From Catalog:
      Desc. Field- added "cell-permeable
      Toxicity Standard Handling
      ReferencesChen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
      Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.