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557368 Rotenone - CAS 83-79-4 - Calbiochem

A mitochondrial toxin and a potent, reversible, and competitive inhibitor of complex I (NADH-CoQ reductase) of the respiratory chain.

Rotenone - CAS 83-79-4 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Primary Target: NADH-CoQ reductase
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557368
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
83-79-4C₂₃H₂₂O₆

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      Description
      OverviewA mitochondrial toxin and a potent, reversible, and competitive inhibitor of complex I (NADH-CoQ reductase) of the respiratory chain. Also inhibits cellular proliferation in mouse liver.
      Catalogue Number557368
      Brand Family Calbiochem®
      References
      ReferencesKopustinskiene, D.M., et al. 2001. Eur. J. Pharmacol. 428, 311.
      Higgins, D.S., Jr. and Greenamyre, J.T. 1996. J. Neurosci. 16, 3807.
      Cunningham, M.L., et al. 1995. Cancer Lett. 95, 93.
      Product Information
      CAS number83-79-4
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₂₃H₂₂O₆
      Chemical formulaC₂₃H₂₂O₆
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNADH-CoQ reductase
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSDJ2800000
      Safety Information
      R PhraseR: 25-36/37/38-50/53

      Toxic if swallowed.
      Irritating to eyes, respiratory system and skin.
      Very toxic to aquatic organisms; may cause long-term adverse effects in the aquatic environment.
      S PhraseS: 22-24/25-36-45-60-61

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      This material and its container must be disposed of as hazardous waste.
      Avoid release to the environment. Refer to special instructions/safety data sheet.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, flush with nitrogen, and store at -70°C. Stock solutions are stable for up to 1 month at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      557368-1GM 04055977268034

      Documentation

      Rotenone - CAS 83-79-4 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Rotenone - CAS 83-79-4 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      557368

      Références bibliographiques

      Aperçu de la référence bibliographique
      Kopustinskiene, D.M., et al. 2001. Eur. J. Pharmacol. 428, 311.
      Higgins, D.S., Jr. and Greenamyre, J.T. 1996. J. Neurosci. 16, 3807.
      Cunningham, M.L., et al. 1995. Cancer Lett. 95, 93.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-October-2019 JSW
      DescriptionA mitochondrial toxin and a potent, reversible and competitive inhibitor of complex I (NADH-CoQ reductase) of the respiratory chain. Also inhibits cellular proliferation in mouse liver.
      FormWhite to off-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number83-79-4
      RTECSDJ2800000
      Chemical formulaC₂₃H₂₂O₆
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityChloroform (50 mg/ml), DMSO (50 mg/ml), or ethanol (5 mg/ml)
      Storage Protect from light
      +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, flush with nitrogen, and store at -70°C. Stock solutions are stable for up to 1 month at -70°C.
      Toxicity Toxic
      Merck USA index14 8271
      ReferencesKopustinskiene, D.M., et al. 2001. Eur. J. Pharmacol. 428, 311.
      Higgins, D.S., Jr. and Greenamyre, J.T. 1996. J. Neurosci. 16, 3807.
      Cunningham, M.L., et al. 1995. Cancer Lett. 95, 93.