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557514 Ro-31-8425 - CAS 131848-97-0 - Calbiochem

A potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC₅₀ = 15 nM for rat brain PKC).

Ro-31-8425 - CAS 131848-97-0 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 2-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide X, HCl

Primary Target: PKC
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557514
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Tableau de caractéristiques principal

CAS #Empirical Formula
131848-97-0C₂₆H₂₄N₄O₂ · HCl

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      Description
      OverviewA potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC50 = 15 nM for rat brain PKC). Exhibits some degree of isozyme specificity (IC50 = 8 nM for PKCα, 8 nM for PKCβI, 14 nM for PKCβII, 13 nM for PKCγ, and 39 nM for PKCε). Upregulates CD11a expression and enhances mesenchymal stromal cell adhesion under flow.
      Catalogue Number557514
      Brand Family Calbiochem®
      Synonyms2-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide X, HCl
      References
      ReferencesLevy, O., et al. 2015. Cell Reports 10, In press.
      Merritt, J.E., et al. 1997. Cell Signal 9, 53.
      Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
      Product Information
      CAS number131848-97-0
      ATP CompetitiveY
      FormRed to orange-red solid
      Hill FormulaC₂₆H₂₄N₄O₂ · HCl
      Chemical formulaC₂₆H₂₄N₄O₂ · HCl
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKC
      Primary Target IC<sub>50</sub>15 nM for rat brain PKC; 8 nM for PKCα, 8 nM for PKCβI, 14 nM for PKCβII, 13 nM for PKCγ, and 39 nM for PKCε
      Purity≥94% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      557514-1MG 04055977192971

      Documentation

      Ro-31-8425 - CAS 131848-97-0 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Ro-31-8425 - CAS 131848-97-0 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      557514

      Références bibliographiques

      Aperçu de la référence bibliographique
      Levy, O., et al. 2015. Cell Reports 10, In press.
      Merritt, J.E., et al. 1997. Cell Signal 9, 53.
      Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-May-2018 JSW
      Synonyms2-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide X, HCl
      DescriptionA potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC50 = 15 nM for rat brain PKC). Exhibits some degree of isozyme specificity (IC50 = 8 nM for PKCα, 8 nM for PKCβI, 14 nM for PKCβII, 13 nM for PKCγ, and 39 nM for PKCε). Shows slight selectivity for the conventional PKC isozymes PKCα, PKCβ, and PKCγ over the Ca2+-independent PKC isozyme PKCε. Upregulates CD11a expression and enhances mesenchymal stromal cell adhesion under flow.
      FormRed to orange-red solid
      CAS number131848-97-0
      Chemical formulaC₂₆H₂₄N₄O₂ · HCl
      Structure formulaStructure formula
      Purity≥94% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesLevy, O., et al. 2015. Cell Reports 10, In press.
      Merritt, J.E., et al. 1997. Cell Signal 9, 53.
      Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.