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553014 Raf Kinase Inhibitor IV - CAS 303727-31-3 - Calbiochem

The Raf Kinase Inhibitor IV, also referenced under CAS 303727-31-3, controls the biological activity of Raf Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole, L 779450

Primary Target: Raf Kinase
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553014
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Tableau de caractéristiques principal

CAS #Empirical Formula
303727-31-3C₂₀H₁₄ClN₃O

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      Description
      OverviewA cell-permeable triarylimidazole compound that acts as a reversible, ATP-competitive, and highly potent inhibitor of Raf kinase (IC50 = 10 nM and Kd = 2.4 nM for B-raf) with 7-, 30-, and 70-fold selectivity over p38α, GSK-3β, and Lck, respectively. Cellular data have indicated that the compound is more effective towards Raf-1and A-Raf than B-Raf.
      Catalogue Number553014
      Brand Family Calbiochem®
      Synonyms2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole, L 779450
      References
      ReferencesTakle, A.K., et al. 2006. Bioorg. Med. Chem. Lett. 16, 378.
      Shelton, J.G., et al. 2003. Leukemia 17, 1765.
      Product Information
      CAS number303727-31-3
      ATP CompetitiveY
      FormOff-white solid
      Hill FormulaC₂₀H₁₄ClN₃O
      Chemical formulaC₂₀H₁₄ClN₃O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetRaf Kinase
      Primary Target IC<sub>50</sub>10 nM; Kd = 2.4 nM for B-raf
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      553014-1MG 04055977193428

      Documentation

      Raf Kinase Inhibitor IV - CAS 303727-31-3 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Raf Kinase Inhibitor IV - CAS 303727-31-3 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      553014

      Références bibliographiques

      Aperçu de la référence bibliographique
      Takle, A.K., et al. 2006. Bioorg. Med. Chem. Lett. 16, 378.
      Shelton, J.G., et al. 2003. Leukemia 17, 1765.

      Posters

      Titre
      Human Kinome & InhibitorSelect™ Libraries
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-May-2011 RFH
      Synonyms2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole, L 779450
      DescriptionA cell-permeable triarylimidazole compound that acts as a reversible, ATP-competitive, and highly potent inhibitor of Raf kinase (IC50 = 10 nM & Kd = 2.4 nM for B-raf) with 7-, 30-, and 70-fold selectivity over p38α, GSK-3β, and Lck, respectively. Cellular data have indicated that the compound is more effective towards Raf-1and A-Raf than B-Raf.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number303727-31-3
      Chemical formulaC₂₀H₁₄ClN₃O
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml) or EtOH (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesTakle, A.K., et al. 2006. Bioorg. Med. Chem. Lett. 16, 378.
      Shelton, J.G., et al. 2003. Leukemia 17, 1765.