529685 Sigma-AldrichProdigiosin Serratia marcescens - CAS 82-89-3 - Calbiochem
A cell-permeable tripyrrole alkaloid compound that displays immunosuppressive and anti-tumor properties irrespective of p53 status and multidrug resistance.
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Synonymes: Casein Kinase I Inhibitor IV, 2-Methyl-3-pentyl-6-methoxyprodigiosene, NSC 47147
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Aperçu
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Tableau de caractéristiques principal
| CAS # | Empirical Formula |
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| 82-89-3 | C₂₀H₂₅N₃O |
Prix & Disponibilité
| Référence | Disponibilité | Conditionnement | Qté | Prix | Quantité | |
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| 529685-200UG |
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Flacon en verre | 200 μg |
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| Description | |
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| Overview | A cell-permeable tripyrrole alkaloid compound that displays immunosuppressive and anti-tumor properties irrespective of p53 status and multidrug resistance. Shown to selectively upregulate p21WAF/CIP1 and NAG-1 (nonsteroidal anti-inflammatory drug-activated gene 1) and downregulate survivin expression levels, induce mitochondria-mediated apoptosis and cell cycle arrest in tumor cells. Prevents FADD phosphorylation (IC50 = 2.0 µM in A549-FKR cells) through inhibition of FADD-kinase CK1α (IC50 ~ 6.0 µM in SW620-BGCR cells) and augments cisplatin (Cat. No. 232120)-induced apoptosis. Blocks NF-κB activation by decreasing pIκBα (by 63% at 3 µM) and IκBα levels in A549 cells, and shrinks tumor growth in A549-FKR tumor xenograft mouse model (3 mg/kg, i.p., o.d.). |
| Catalogue Number | 529685 |
| Brand Family | Calbiochem® |
| Synonyms | Casein Kinase I Inhibitor IV, 2-Methyl-3-pentyl-6-methoxyprodigiosene, NSC 47147 |
| Product Information | |
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| CAS number | 82-89-3 |
| Form | Dark red solid |
| Hill Formula | C₂₀H₂₅N₃O |
| Chemical formula | C₂₀H₂₅N₃O |
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| Quality Level | MQ100 |
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| Purity | ≥95% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Référence | GTIN |
| 529685-200UG | 04055977269314 |
Documentation
Prodigiosin Serratia marcescens - CAS 82-89-3 - Calbiochem FDS
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Prodigiosin Serratia marcescens - CAS 82-89-3 - Calbiochem Certificats d'analyse
| Titre | Numéro de lot |
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| 529685 |
Références bibliographiques
| Aperçu de la référence bibliographique |
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| Schinske, K.A., et al. 2011. Mol. Cancer Ther. 10, 1807. Chang, C.C., et al. 2011. J. Biosci. Bioeng. 5, 501 Ho, T.F., et al. 2009. Toxicol. Appl. Pharmacol. 235, 253 Soto-Cerrato, V., et al. 2007.Mol. Cancer Ther. 6, 362. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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