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AG216 Presenilin-2, blocking peptide for AB5056

Research Category: Neuroscience Research Sub-Category: Neurodegenerative Diseases Gene Symbol: PSEN2, AD5, AD3L, STM2, STM-2, AD3LP, E5-1, Presenilin-2, PSNL2, PS-2, PS2, AD4, EC 3.4.23.- [Contains: Presenilin-2 NTF subunit, Presenilin-2 CTF subunit]. UniProt Number: P49810
AG216
100 µg  
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      Description
      Catalogue NumberAG216
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionPresenilin-2, blocking peptide for AB5056
      OverviewSynthetic peptide from the N-terminal of human presenilin-2.
      References
      Product Information
      PresentationLiquid in sterile water. Contains no preservative.
      Quality LevelMQ300
      Applications
      Key Applications
      • Cell Function Assay
      Application NotesFor use in blocking the reactivity of AB5056.

      Optimal working dilution must be determined by the end user.
      Biological Information
      Concentration1.0 mg/mL
      Entrez Gene Number
      Entrez Gene SummaryAlzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.
      Gene Symbol
      • PSEN2
      • AD5
      • AD3L
      • STM2
      • STM-2
      • AD3LP
      • E5-1
      • Presenilin-2
      • PSNL2
      • PS-2
      • PS2
      • AD4
      • EC 3.4.23.- [Contains: Presenilin-2 NTF subunit
      • Presenilin-2 CTF subunit].
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P49810 # Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.
      SIZE: 448 amino acids; 50140 Da
      SUBUNIT: Interacts with DOCK3 (By similarity). Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist. Interacts with HERPUD1, FLNA, FLNB and PARL.
      SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney.
      DOMAIN: SwissProt: P49810 The PAL motif is required for normal active site conformation (By similarity).
      PTM: Heterogeneous proteolytic processing generates N-terminal and C-terminal fragments. & Phosphorylated on serine residues.
      DISEASE: SwissProt: P49810 # Defects in PSEN2 are the cause of Alzheimer disease type 4 (AD4) [MIM:606889, 104300]. AD is an autosomal dominant neurodegenerative disorder characterized by progressive dementia, parkinsonism, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. Early onset AD is the most severe form of the disease, with complete penetrance and an onset occurring as early as 30 years of age. The second form is late- onset AD (LOAD), with mean age of onset greater than 58 years. & Three causative genes have been identified that when mutated lead to presenile Alzheimer
      DISEASE: APP (amyloid precursor protein gene), PSEN1 and PSEN2. These three genes account for half of the families with autosomal dominant presenile AD, which represent approximately 10% of the whole AD population. In addition, apolipoprotein E has been identified as a risk- modifying locus.
      SIMILARITY: Belongs to the peptidase A22A family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C to -70°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      AG216 04053252404672

      Documentation