Millipore Sigma Vibrant Logo

530618 Pin1 Inhibitor, DTM - CAS 725-32-6 - Calbiochem

A cell permeable competitive inhibitor of Pin1 (EC₅₀ = 4.1 µM, Ki = 50 nM).

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: PPIase-Parvulin Inhibitor II

Primary Target: Pin1
View Products on Sigmaaldrich.com
530618
Voir les Prix & la Disponibilité

Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
725-32-6C₁₂H₂₀N₂S₃

Prix & Disponibilité

Référence DisponibilitéConditionnement Qté Prix Quantité
5.30618.0001
Récupération des données relatives à la disponibilité...
—
Disponibilité limitée Disponibilité limitée
En stock 
Interrompu(e)
Disponible en quantités limitées
Disponibilité à confirmer
    Pour le restant : Nous vous tiendrons informé
      Pour le restant : Nous vous tiendrons informé
      Nous vous tiendrons informé
      Contacter le Service Clients
      Contact Customer Service

      		 Flacon en verre 10 mg
      Prix en cours de récupération
      Le prix n'a pas pu être récupéré
      La quantité minimale doit être un multiple de
      Maximum Quantity is
      À la validation de la commande Plus d'informations
      Vous avez sauvegardé ()
       
      —
      Demander le prix
      		 —
      Description
      OverviewA cell permeable thiuram monosulfide based compound that acts as a competitive inhibitor of Pin1 (EC50 = 4.1 µM, Ki = 50 nM). Binds to the active site of the PPIase domain of Pin1 hydrophobically and blocks the active pocket. Shown to specifically inhibit peptidyl-prolyl cis/trans isomerase activity in HeLa cells. Inhibits the proliferation of HCT116 cells (EC50 = 10 µM) by arresting cell cycle at the G0 phase. Also shown to reduce the endogenous Runx2 protein levels in the MC3T3-E1 cells. Displays excellent solubility in DMSO (~100 mM).

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number530618
      Brand Family Calbiochem®
      SynonymsPPIase-Parvulin Inhibitor II
      References
      ReferencesYoon, W-J., et al. 2013. J. Cell Physiol. 228, 2377.
      Tatara, Y., et al. 2009.Biochem Biophys Res Commun. 384, 394.
      Product Information
      CAS number725-32-6
      FormYellow powder
      Hill FormulaC₁₂H₂₀N₂S₃
      Chemical formulaC₁₂H₂₀N₂S₃
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPin1
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      5.30618.0001 04055977260984

      Documentation

      Pin1 Inhibitor, DTM - CAS 725-32-6 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Yoon, W-J., et al. 2013. J. Cell Physiol. 228, 2377.
      Tatara, Y., et al. 2009.Biochem Biophys Res Commun. 384, 394.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-May-2014 JSW
      SynonymsPPIase-Parvulin Inhibitor II
      DescriptionA cell permeable thiuram monosulfide based compound that acts as a competitive inhibitor of Pin1 (EC50 = 4.1 µM, Ki = 50 nM). Binds to the active site of the PPIase domain of Pin1 hydrophobically and blocks the active pocket. Shown to specifically inhibit peptidyl-prolyl cis/trans isomerase activity in HeLa cells. Inhibits the proliferation of HCT116 cells (EC50 = 10 µM) by arresting cell cycle at the G0 phase. Also shown to reduce the endogenous Runx2 protein levels in the MC3T3-E1 cells. Displays excellent solubility in DMSO (~100 mM).
      FormYellow powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number725-32-6
      Chemical formulaC₁₂H₂₀N₂S₃
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesYoon, W-J., et al. 2013. J. Cell Physiol. 228, 2377.
      Tatara, Y., et al. 2009.Biochem Biophys Res Commun. 384, 394.