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524488 Phloretin - CAS 60-82-2 - Calbiochem

A cell-permeable inhibtor of protein kinase C (IC₅₀ = 20-50 µM).

Phloretin - CAS 60-82-2 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 2ʹ,4ʹ,6ʹ-Trihydroxy-3-p-hydroxyphenylpropiophenone

Primary Target: PKC
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524488
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Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
60-82-2C₁₅H₁₄O₅

Prix & Disponibilité

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524488-200MG
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      		 Ampoule plast. 200 mg
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      Description
      OverviewA cell-permeable inhibtor of protein kinase C (IC50 = 20-50 µM). Activates Ca2+-activated K+ channels in amphibian myelinated nerve fibers at micromolar concentrations. An inhibitor of myo-inositol uptake. Also inhibits L-type Ca2+ channel activity. A potent inhibitor of 5′-iodothyronine deiodinase. Antagonist of prostaglandin F2α receptors linked to phospholipase C in astrocytes.
      Catalogue Number524488
      Brand Family Calbiochem®
      Synonyms2ʹ,4ʹ,6ʹ-Trihydroxy-3-p-hydroxyphenylpropiophenone
      References
      ReferencesBerry, G.T., et al. 1994. Pediat. Res. 35, 141.
      Koh, D.S., et al. 1994. Neurosci. Lett. 165, 167.
      Morreale de Escobar, G., et al. 1994. Endocrinology 134, 2410.
      Prevarskaya, N., et al. 1994. Mol. Cell. Neurosci. 5, 699.
      Kitanaka, J., et al. 1993. J. Neurochem. 60, 704.
      Wang, X., et al. 1993. Biochem. J. 290, 249.
      Benga, G., et al. 1992. Eur. J. Cell Biol. 59, 219.
      Jordan, M.L., and Wright, J. 1991. J. Surg. Res. 50, 569.
      Product Information
      CAS number60-82-2
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₅H₁₄O₅
      Chemical formulaC₁₅H₁₄O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKC
      Primary Target IC<sub>50</sub>20-50 µM against protein kinase C
      Purity≥97% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      524488-200MG 04055977270990

      Documentation

      Phloretin - CAS 60-82-2 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Phloretin - CAS 60-82-2 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      524488

      Références bibliographiques

      Aperçu de la référence bibliographique
      Berry, G.T., et al. 1994. Pediat. Res. 35, 141.
      Koh, D.S., et al. 1994. Neurosci. Lett. 165, 167.
      Morreale de Escobar, G., et al. 1994. Endocrinology 134, 2410.
      Prevarskaya, N., et al. 1994. Mol. Cell. Neurosci. 5, 699.
      Kitanaka, J., et al. 1993. J. Neurochem. 60, 704.
      Wang, X., et al. 1993. Biochem. J. 290, 249.
      Benga, G., et al. 1992. Eur. J. Cell Biol. 59, 219.
      Jordan, M.L., and Wright, J. 1991. J. Surg. Res. 50, 569.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-January-2012 JSW
      Synonyms2ʹ,4ʹ,6ʹ-Trihydroxy-3-p-hydroxyphenylpropiophenone
      DescriptionA cell-permeable inhibtor of protein kinase C (IC50 = 20-50 µM). Activates Ca2+-activated K+ channels in amphibian myelinated nerve fibers at micromolar concentrations. An inhibitor of myo-inositol uptake. Also inhibits L-type Ca2+ channel activity. A potent inhibitor of 5′-iodothyronine deiodinase. Antagonist of prostaglandin F2α receptors linked to phospholipase C in astrocytes.
      FormWhite solid
      CAS number60-82-2
      Chemical formulaC₁₅H₁₄O₅
      Structure formulaStructure formula
      Purity≥97% by TLC
      SolubilityAcetone, ethanol, or methanol
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 1 month at -20°C.
      Toxicity Irritant
      Merck USA index14, 7326
      ReferencesBerry, G.T., et al. 1994. Pediat. Res. 35, 141.
      Koh, D.S., et al. 1994. Neurosci. Lett. 165, 167.
      Morreale de Escobar, G., et al. 1994. Endocrinology 134, 2410.
      Prevarskaya, N., et al. 1994. Mol. Cell. Neurosci. 5, 699.
      Kitanaka, J., et al. 1993. J. Neurochem. 60, 704.
      Wang, X., et al. 1993. Biochem. J. 290, 249.
      Benga, G., et al. 1992. Eur. J. Cell Biol. 59, 219.
      Jordan, M.L., and Wright, J. 1991. J. Surg. Res. 50, 569.