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52332 Phenylmethylsulfonyl Fluoride - CAS 329-98-6 - Calbiochem

Phenylmethylsulfonyl Fluoride, CAS 329-98-6, is an irreversible inhibitor of serine proteases. It causes sulfonylation of the active-site serine residues.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Benzylsulfonyl Fluoride, PMSF

Primary Target: serine proteases
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      329-98-6C₇H₇FO₂S
      Description
      OverviewIrreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes. For a related, more stable inhibitor, see AEBSF (Cat. No. 101500).
      Catalogue Number52332
      Brand Family Calbiochem®
      SynonymsBenzylsulfonyl Fluoride, PMSF
      References
      ReferencesSeitz, R., et al. 1993. Int. J. Cancer 53, 514.
      Weaver, V.M., et al. 1993. Biochem. Cell. Biol. 71, 488.
      Bourgain, R.H., et al. 1992. Adv. Exp. Med. Biol. 316, 427.
      Chang, C.T., et al. 1992. Biochem. Int. 28, 707.
      Product Information
      CAS number329-98-6
      ATP CompetitiveN
      FormWhite to off-white crystalline solid
      Hill FormulaC₇H₇FO₂S
      Chemical formulaC₇H₇FO₂S
      HS Code2904 99 90
      Reconstitutiont½ = 1 hour at pH 7.5. Effective concentration: 50 μM.
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      Biological Information
      Primary Targetserine proteases
      Purity≥99% by GC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSXT8040000
      Safety Information
      R PhraseR: 34

      Causes burns.
      S PhraseS: 26-36/37/39-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Corrosive
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +15°C to +30°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 9 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      52332 0

      Documentation

      Phenylmethylsulfonyl Fluoride - CAS 329-98-6 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Phenylmethylsulfonyl Fluoride - CAS 329-98-6 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      52332

      Références bibliographiques

      Aperçu de la référence bibliographique
      Seitz, R., et al. 1993. Int. J. Cancer 53, 514.
      Weaver, V.M., et al. 1993. Biochem. Cell. Biol. 71, 488.
      Bourgain, R.H., et al. 1992. Adv. Exp. Med. Biol. 316, 427.
      Chang, C.T., et al. 1992. Biochem. Int. 28, 707.

      Brochure

      Titre
      Caspases and other Apoptosis Related Tools Brochure

      Citations

      Titre
    • Sun, G., et al. 2007. Journal of Bacteriology 189, 6222.
      		•
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-August-2008 RFH
      SynonymsBenzylsulfonyl Fluoride, PMSF
      DescriptionIrreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes. Effective at a concentration of 50 µM.
      FormWhite to off-white crystalline solid
      CAS number329-98-6
      RTECSXT8040000
      Chemical formulaC₇H₇FO₂S
      Structure formulaStructure formula
      Purity≥99% by GC
      SolubilityEthanol, isopropanol, or methanol
      Storage Protect from moisture
      +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 9 months at 4°C.
      Toxicity Corrosive
      ReferencesSeitz, R., et al. 1993. Int. J. Cancer 53, 514.
      Weaver, V.M., et al. 1993. Biochem. Cell. Biol. 71, 488.
      Bourgain, R.H., et al. 1992. Adv. Exp. Med. Biol. 316, 427.
      Chang, C.T., et al. 1992. Biochem. Int. 28, 707.
      Citation
    • Sun, G., et al. 2007. Journal of Bacteriology 189, 6222.
      		•