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540210 PTP Inhibitor III - CAS 29936-81-0 - Calbiochem

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: α-Bromo-4-(carboxymethoxy)acetophenone, 4-(Carboxymethoxy)phenacyl Br, Protein Tyrosine Phosphatase Inhibitor III, SHP1 Inhibitor III, PTP-MEG2/PTPN9 Inhibitor, PTP-β Inhibitor, PTP-δ Inhibitor, PTP-ε Inhibitor, PTP-µ Inhibitor, PTP1B Inhibitor III, SHP2 Inhibitor II

Primary Target: protein tyrosine phosphatase (PTP)
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      29936-81-0C₁₀H₉BrO₄
      Description
      Overview

      This product has been discontinued.



      A potent, cell-permeable, and covalent protein tyrosine phosphatase (PTP) inhibitor. Binds to SHP-1 (ΔSH2), the catalytic domain of the SH2 domain-containing phosphatase SHP-1, with lower affinity than PTP Inhibitor I (Cat. No. 540200) (Ki = 193 µM versus Ki = 43 µM) but with a higher kinact (1.8 min-1 versus 0.4 min-1). The inhibition can be reversed by irradiation of the inactivated PTP at 350 nm.
      Catalogue Number540210
      Brand Family Calbiochem®
      Synonymsα-Bromo-4-(carboxymethoxy)acetophenone, 4-(Carboxymethoxy)phenacyl Br, Protein Tyrosine Phosphatase Inhibitor III, SHP1 Inhibitor III, PTP-MEG2/PTPN9 Inhibitor, PTP-β Inhibitor, PTP-δ Inhibitor, PTP-ε Inhibitor, PTP-µ Inhibitor, PTP1B Inhibitor III, SHP2 Inhibitor II
      References
      ReferencesArabaci, G., et al. 1999. J. Am. Chem. Soc. 121, 5085.
      Product Information
      CAS number29936-81-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₀H₉BrO₄
      Chemical formulaC₁₀H₉BrO₄
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetprotein tyrosine phosphatase (PTP)
      Primary Target IC<sub>50</sub>193 µM against PTP
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 34-36/37

      Causes burns.
      Irritating to eyes and respiratory system.
      S PhraseS: 26-27-28-36/37/39

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Take off immediately all contaminated clothing.

      Wear suitable protective clothing, gloves and eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Corrosive
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage ≤ -70°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsUnstable in DMSO; reconstitute just prior to use. Following initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      540210 0

      Documentation

      PTP Inhibitor III - CAS 29936-81-0 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      PTP Inhibitor III - CAS 29936-81-0 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      540210

      Références bibliographiques

      Aperçu de la référence bibliographique
      Arabaci, G., et al. 1999. J. Am. Chem. Soc. 121, 5085.

      Brochure

      Titre
      Protein Phosphatases Technical Bulletin
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-April-2011 RFH
      Synonymsα-Bromo-4-(carboxymethoxy)acetophenone, 4-(Carboxymethoxy)phenacyl Br, Protein Tyrosine Phosphatase Inhibitor III, SHP1 Inhibitor III, PTP-MEG2/PTPN9 Inhibitor, PTP-β Inhibitor, PTP-δ Inhibitor, PTP-ε Inhibitor, PTP-µ Inhibitor, PTP1B Inhibitor III, SHP2 Inhibitor II
      DescriptionA potent, cell-permeable, and covalent Protein Tyrosine Phosphatase (PTP) inhibitor. Binds to SHP-1(ΔSH2), the catalytic domain of the SH2 domain-containing phosphatase SHP-1, with lower affinity that PTP Inhibitor I (Cat. No. 540200) (Ki = 193 µM versus Ki = 43 mM) but with a higher kinact (1.8 min-1 versus 0.40 min-1). The inhibition can be reversed by irradiation of the inactivated PTP at 350 nm.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number29936-81-0
      Chemical formulaC₁₀H₉BrO₄
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (200 mg/ml)
      Storage Protect from light
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsUnstable in DMSO; reconstitute just prior to use. Following initial thaw, aliquot and freeze (-70°C).
      Toxicity Corrosive
      ReferencesArabaci, G., et al. 1999. J. Am. Chem. Soc. 121, 5085.