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505278 PNU 282987 - CAS 123464-89-1 - Calbiochem

PNU 282987 - CAS 123464-89-1 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: PNU-282987, N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide hydrochloride, α7 nAChR Agonist, PNU 282987, alpha 7 Nicotinic Acetylcholine Receptor Agonist, PNU 282987, PNU282987

Primary Target: α7 nAChRs
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      123464-89-1C₁₄H₁₇ClN₂O•HCl
      Description
      Overview

      This product has been discontinued.



      A potent agonist highly selective for α7 nAChRs (Ki = 26 nM). Used in investigating the roles of α7 nAChRs in sensory gating, learning and memory, cognitive functions, and treatment of Schizophrenia.
      Catalogue Number505278
      Brand Family Calbiochem®
      SynonymsPNU-282987, N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide hydrochloride, α7 nAChR Agonist, PNU 282987, alpha 7 Nicotinic Acetylcholine Receptor Agonist, PNU 282987, PNU282987
      References
      ReferencesHajós, M., et al., 2010, Curr. Pharm. Des. 16, 538.
      Bodnar, L., et al., 2005. J. Med. Chem. 48, 905.
      Hajós, M., et al., 2005. J. Pharmacol. Exp. Ther. 312, 1213.
      Product Information
      CAS number123464-89-1
      FormOff-white solid
      Hill FormulaC₁₄H₁₇ClN₂O•HCl
      Chemical formulaC₁₄H₁₇ClN₂O•HCl
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetα7 nAChRs
      Primary Target K<sub>i</sub>26 nM
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      505278 0

      Documentation

      PNU 282987 - CAS 123464-89-1 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Hajós, M., et al., 2010, Curr. Pharm. Des. 16, 538.
      Bodnar, L., et al., 2005. J. Med. Chem. 48, 905.
      Hajós, M., et al., 2005. J. Pharmacol. Exp. Ther. 312, 1213.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-July-2013 JSW
      SynonymsPNU-282987, N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide hydrochloride, α7 nAChR Agonist, PNU 282987, alpha 7 Nicotinic Acetylcholine Receptor Agonist, PNU 282987, PNU282987
      DescriptionA potent agonist highly selective for α7 nAChRs (Ki = 26 nM). Used in investigating the roles of α7 nAChRs in sensory gating, learning and memory, cognitive functions, and treatment of Schizophrenia.
      FormOff-white solid
      CAS number123464-89-1
      Chemical formulaC₁₄H₁₇ClN₂O•HCl
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityH₂O (100 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHajós, M., et al., 2010, Curr. Pharm. Des. 16, 538.
      Bodnar, L., et al., 2005. J. Med. Chem. 48, 905.
      Hajós, M., et al., 2005. J. Pharmacol. Exp. Ther. 312, 1213.