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513022 PD 150606 - CAS 426821-41-2 - Calbiochem

A cell-permeable, non-competitive, selective non-peptide calpain inhibitor [Ki = 210 nM for calpain-1 and 370 nM for calpain-2.

PD 150606 - CAS 426821-41-2 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic Acid

Primary Target: Calpain-1
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513022
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Tableau de caractéristiques principal

CAS #Empirical Formula
426821-41-2C₉H₇IO₂S

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513022-5MG
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      Description
      OverviewA cell-permeable, non-competitive, selective non-peptide calpain inhibitor [Ki = 210 nM for calpain-1 (Cat. Nos. 208712 and 208713) and 370 nM for calpain-2 (Cat. Nos. 208715 and 208718)] directed towards the calcium binding sites of calpain. Exhibits high specificity for calpains relative to other proteases, such as cathepsin B and cathepsin L. Does not shield calpain against inactivation by the active-site inhibitor trans-(epoxysuccinyl)-L-leucyl-amido-3-methylbutane. Reportedly prevents dexamethasone-induced apoptosis in thymocytes.
      Catalogue Number513022
      Brand Family Calbiochem®
      Synonyms3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic Acid
      References
      ReferencesLin, G.D., et al. 1997. Nat. Struct. Biol. 4, 539.
      Squier, M.K., and Cohen, J.J. 1997. J. Immunol. 158, 3960.
      Edelstein, C.L., et al. 1996. Kidney Int. 50, 1150.
      Wang, K.K.W., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6687.
      Product Information
      CAS number426821-41-2
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₉H₇IO₂S
      Chemical formulaC₉H₇IO₂S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCalpain-1
      Primary Target K<sub>i</sub>210 nM for calpain-1 and 370 nM for calpain-2
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      513022-5MG 04055977198591

      Documentation

      PD 150606 - CAS 426821-41-2 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      PD 150606 - CAS 426821-41-2 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      513022

      Références bibliographiques

      Aperçu de la référence bibliographique
      Lin, G.D., et al. 1997. Nat. Struct. Biol. 4, 539.
      Squier, M.K., and Cohen, J.J. 1997. J. Immunol. 158, 3960.
      Edelstein, C.L., et al. 1996. Kidney Int. 50, 1150.
      Wang, K.K.W., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6687.

      Citations

      Titre
    • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
      		•
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-April-2011 RFH
      Synonyms3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic Acid
      DescriptionA cell-permeable, selective non-peptide calpain inhibitor (Ki = 210 nM for calpain I and 370 nM for calpain II) directed towards the calcium- binding sites of calpain. Exhibits high specificity for calpains relative to other proteases, such as cathepsin B and L. PD 150606 is a non-competitive inhibitor with respect to the substrate and does not shield calpain against inactivation by the active-site inhibitor trans-(epoxysuccinyl)-L-leucyl-amido-3-methylbutane. Reportedly prevents dexamethasone-induced apoptosis of thymocytes.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number426821-41-2
      Chemical formulaC₉H₇IO₂S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml) or Methanol (25 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesLin, G.D., et al. 1997. Nat. Struct. Biol. 4, 539.
      Squier, M.K., and Cohen, J.J. 1997. J. Immunol. 158, 3960.
      Edelstein, C.L., et al. 1996. Kidney Int. 50, 1150.
      Wang, K.K.W., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6687.
      Citation
    • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
      		•