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528824 PARP Inhibitor XIV - CAS 1104546-89-5 - Calbiochem

The PARP Inhibitor XIV, also referenced under CAS 1104546-89-5, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 4-(1-Methyl-1H-pyrrol-2-ylmethylene)-4H-isoquinoline-1,3-dione, BYK204165

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528824
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Tableau de caractéristiques principal

CAS #Empirical Formula
1104546-89-5C₁₅H₁₂N₂O₂

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528824-10MG
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      		 Ampoule plast. 10 mg
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      Description
      OverviewA cell-permeable isoquinolinedione compound that potently inhibits PARP-1 activity (pIC50 = 7.35; IC50 = 45 nM) in a NAD+-competitive and reversible manner, while affecting PPAR-2 activity with a 100-fold lower potency. Selectively inhibits PARP-1-mediated cellular PAR formation and is of little effect against PAR formation in fibroblasts derived from parp-1(-/-) mice. Its in vivo application is limited by a poor aqueous solubility (~9 µM).
      Catalogue Number528824
      Brand Family Calbiochem®
      Synonyms4-(1-Methyl-1H-pyrrol-2-ylmethylene)-4H-isoquinoline-1,3-dione, BYK204165
      References
      ReferencesEltze, T., et al. 2008. Mol. Pharmacol. 74, 1587.
      Product Information
      CAS number1104546-89-5
      FormOrange solid
      Hill FormulaC₁₅H₁₂N₂O₂
      Chemical formulaC₁₅H₁₂N₂O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC (sum of two isomers)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      528824-10MG 04055977196641

      Documentation

      PARP Inhibitor XIV - CAS 1104546-89-5 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      PARP Inhibitor XIV - CAS 1104546-89-5 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      528824

      Références bibliographiques

      Aperçu de la référence bibliographique
      Eltze, T., et al. 2008. Mol. Pharmacol. 74, 1587.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-April-2011 RFH
      Synonyms4-(1-Methyl-1H-pyrrol-2-ylmethylene)-4H-isoquinoline-1,3-dione, BYK204165
      DescriptionA cell-permeable isoquinolinedione compound that potently inhibits PARP-1 activity (pIC50 = 7.35; IC50 = 45 nM) in a NAD+-competitive and reversible manner, while affecting PPAR-2 activity with a 100-fold lower potency. Selectively inhibits PARP-1-mediated cellular PAR formation and is of little effect against PAR formation in fibroblasts derived from parp-1(-/-) mice. Its in vivo application is limited by a poor aqueous solubility (~9 µM).
      FormOrange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1104546-89-5
      Chemical formulaC₁₅H₁₂N₂O₂
      Structure formulaStructure formula
      Purity≥97% by HPLC (sum of two isomers)
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesEltze, T., et al. 2008. Mol. Pharmacol. 74, 1587.