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324473 PARP Inhibitor IX, EB-47 - Calbiochem

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Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₂₄H₂₇N₉O₆·2HCl·2H₂O

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324473-1MG
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      Description
      OverviewA cell-permeable, adenosine-substituted, isoindolinone compound that acts as a potent inhibitor of PARP-1 (IC50 = 45 nM). Shown to offer cytoprotective effects against oxidative damage in cells and in in vivo models of reperfusion injury and inflammation.
      Catalogue Number324473
      Brand Family Calbiochem®
      References
      ReferencesJagtap, P.G., et al. 2004. Bioorg. Med. Chem. Lett. 14, 81.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₄H₂₇N₉O₆·2HCl·2H₂O
      Chemical formulaC₂₄H₂₇N₉O₆·2HCl·2H₂O
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPARP-1
      Primary Target IC<sub>50</sub>45 nM
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Carcinogenic / Teratogenic
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      324473-1MG 04055977197235

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      PARP Inhibitor IX, EB-47 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      PARP Inhibitor IX, EB-47 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      324473

      Références bibliographiques

      Aperçu de la référence bibliographique
      Jagtap, P.G., et al. 2004. Bioorg. Med. Chem. Lett. 14, 81.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-June-2008 RFH
      DescriptionA cell-permeable, adenosine-substituted, isoindolinone compound that acts as a potent inhibitor of poly (ADP-ribose) polymerase-1 (PARP-1) (IC50 = 45 nM). Reported to offer cytoprotective effects against oxidative damage in cells and in in vivo models of reperfusion injury and inflammation.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₄H₂₇N₉O₆·2HCl·2H₂O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityH₂O (50 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesJagtap, P.G., et al. 2004. Bioorg. Med. Chem. Lett. 14, 81.