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14-633M PAK6 Protein, active, 250 µg

Active, N-terminal His6-tagged, recombinant, human PAK6, amino acids 382-end, for use in Kinase Assays.

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14-633M
250 µg  Also available in 10 μg size (cat#14-633) and in bulk (cat#14-633-K).
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      Replacement Information
      Description
      Catalogue Number14-633M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionPAK6 Protein, active, 250 µg
      OverviewN-terminal His6-tagged, recombinant, human PAK6, amino acids 382-end
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationActive, N-terminal His6-tagged, recombinant, human PAK6, amino acids 382-end, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourcebaculovirus in Sf21 cells
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen.
      Gene Symbol
      • PAK6
      • PAK-5
      • PAK-6
      • PAK5
      Protein TargetPAK6
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilySTE
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9NQU5 # The activated kinase acts on a variety of targets (By similarity).
      SIZE: 681 amino acids; 74869 Da
      SUBUNIT: Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1 (By similarity). Interacts with the androgen receptor.
      PTM: Autophosphorylated when activated by CDC42/p21 (By similarity).
      SIMILARITY: SwissProt: Q9NQU5 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 CRIB domain. & Contains 1 protein kinase domain.
      Molecular Weight37.9kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of PAKtide
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-633) and in bulk (cat#14-633-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      14-633M 04053252924460

      Documentation

      Produits & Applications associés

      Alternative Packsize

      Référence Description  
      14-633 PAK6 Protein, active, 10 µg Prix & Disponibilité

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      Catégories

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases