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538002 Nurr1 Agonist, SA00025

An orally bioavailable, brain-penetrating, highly potent agonist of nuclear receptor related 1 (Nurr1; EC₅₀ = 2.5 nM in HEK293 cells transfected with full length human Nurr1).

Nurr1 Agonist, SA00025 : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 2-(3-(2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl)phenyl)propan-2-ol, Nuclear Receptor Related 1 Agonist, SA00025

538002
  
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      Aperçu

      Replacement Information
      Description
      Overview

      This product has been discontinued.



      An orally bioavailable, brain-penetrating, imidazo[1,2-a]pyridine derivative that acts as a highly potent agonist of nuclear receptor related 1 (Nurr1; EC50 = 2.5 nM in HEK293 cells transfected with full length human Nurr1). Does not affect a panel of 40 other nuclear receptors, including RXR. Shown to modulate the transcription of dopaminergic target genes when administered orally in rats. Displays anti-inflammatory effects and offers neuroprotection in the 6-OHDA lesion model of Parkinson's disease (30 mg/kg for 7 days, p.o.).

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

      Catalogue Number538002
      Brand Family Calbiochem®
      Synonyms2-(3-(2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl)phenyl)propan-2-ol, Nuclear Receptor Related 1 Agonist, SA00025
      References
      ReferencesSmith, G.A., et al. 2015. Plos One. 10, e0121072.
      Product Information
      FormOff-white or faint peach solid
      Hill FormulaC₂₂H₁₉ClN₂O
      Chemical formulaC₂₂H₁₉ClN₂O
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNurr1
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      538002 0

      Documentation

      Nurr1 Agonist, SA00025 FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Smith, G.A., et al. 2015. Plos One. 10, e0121072.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-September-2016 JSW
      Synonyms2-(3-(2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl)phenyl)propan-2-ol, Nuclear Receptor Related 1 Agonist, SA00025
      DescriptionAn orally bioavailable, brain-penetrating, imidazo[1,2-a]pyridine derivative that acts as a highly potent agonist of nuclear receptor related 1 (Nurr1; EC50 = 2.5 nM in HEK293 cells transfected with full length human Nurr1). Does not affect a panel of 40 other nuclear receptors, including RXR. Shown to modulate the transcription of dopaminergic target genes when administered orally in rats. Displays anti-inflammatory effects and offers neuroprotection in the 6-OHDA lesion model of Parkinson's disease (30 mg/kg for 7 days, p.o.).
      FormOff-white or faint peach solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₂H₁₉ClN₂O
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSmith, G.A., et al. 2015. Plos One. 10, e0121072.