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475843 Minocycline, Hydrochloride - CAS 13614-98-7 - Calbiochem

Semi-synthetic tetracycline derivative effective against tetracycline-resistant staphylococci.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 7-Dimethylamino-6-demethyl-6-deoxytetracycline, HCl

Primary Target: Metalloproteinase (MMP)
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      13614-98-7C₂₃H₂₇N₃O₇ · HCl
      Description
      Overview

      This product has been discontinued.



      Semi-synthetic tetracycline derivative effective against tetracycline-resistant staphylococci. A matrix metalloproteinase (MMP) inhibitor shown to inhibit tumor-induced angiogenesis. Inhibits stromelysin (MMP-3; IC50 = 290 µM) but does not inhibit other MMPs such as fibroblast collagenase or gelatinase. Potently inhibits PARP-1 (Ki = 13.4 nM) in a NAD+ - competitive manner. Exhibits anti-inflammatory effects and suppresses T cell proliferation.
      Catalogue Number475843
      Brand Family Calbiochem®
      Synonyms7-Dimethylamino-6-demethyl-6-deoxytetracycline, HCl
      References
      ReferencesConrad, C.A., et al. 2006. Proc. Natl. Acad, Sci. USA 103, 9685.
      Gilbertson-Breading, S., et al. 1995. Cancer Chemother. Pharmacol. 36, 418.
      Kloppenburg, M., et al. 1995. Clin. Exp. Immunol. 102, 635.
      Preus, H.R., et al. 1995. J. Clin. Periodontol. 22, 380.
      Weingart, J.D., et al. 1995. J. Neurosurg. 82, 635.
      Tamargo, R.J., et al. 1991. Cancer Res. 51, 672.
      Product Information
      CAS number13614-98-7
      ATP CompetitiveN
      FormDark yellow solid
      Hill FormulaC₂₃H₂₇N₃O₇ · HCl
      Chemical formulaC₂₃H₂₇N₃O₇ · HCl
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMetalloproteinase (MMP)
      Primary Target IC<sub>50</sub>290 µM against MMP-3
      Primary Target K<sub>i</sub>13.4 nM against PARP-1
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSQI7630500
      Safety Information
      R PhraseR: 33-36/37/38-63-64

      Danger of cumulative effects.
      Irritating to eyes, respiratory system and skin.
      Possible risk of harm to the unborn child.
      May cause harm to breastfed babies.
      S PhraseS: 22-45-36

      Do not breathe dust.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      475843 0

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Minocycline, Hydrochloride - CAS 13614-98-7 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Minocycline, Hydrochloride - CAS 13614-98-7 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      475843

      Références bibliographiques

      Aperçu de la référence bibliographique
      Conrad, C.A., et al. 2006. Proc. Natl. Acad, Sci. USA 103, 9685.
      Gilbertson-Breading, S., et al. 1995. Cancer Chemother. Pharmacol. 36, 418.
      Kloppenburg, M., et al. 1995. Clin. Exp. Immunol. 102, 635.
      Preus, H.R., et al. 1995. J. Clin. Periodontol. 22, 380.
      Weingart, J.D., et al. 1995. J. Neurosurg. 82, 635.
      Tamargo, R.J., et al. 1991. Cancer Res. 51, 672.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-May-2008 RFH
      Synonyms7-Dimethylamino-6-demethyl-6-deoxytetracycline, HCl
      DescriptionSemi-synthetic tetracycline derivative effective against tetracycline-resistant staphylococci. A matrix metalloproteinase (MMP) inhibitor shown to inhibit tumor-induced angiogenesis. Inhibits stromelysin (MMP-3; IC50 = 290 µM) but does not inhibit other MMPs such as fibroblast collagenase or gelatinase. Potently inhibits PARP-1 (Ki = 13.4 nM) in a NAD+ - competitive manner. Exhibits anti-inflammatory effects and suppresses T cell proliferation.
      FormDark yellow solid
      CAS number13614-98-7
      RTECSQI7630500
      Chemical formulaC₂₃H₂₇N₃O₇ · HCl
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityH₂O (50 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Toxicity Carcinogenic / Teratogenic
      Merck USA index14, 6202
      ReferencesConrad, C.A., et al. 2006. Proc. Natl. Acad, Sci. USA 103, 9685.
      Gilbertson-Breading, S., et al. 1995. Cancer Chemother. Pharmacol. 36, 418.
      Kloppenburg, M., et al. 1995. Clin. Exp. Immunol. 102, 635.
      Preus, H.R., et al. 1995. J. Clin. Periodontol. 22, 380.
      Weingart, J.D., et al. 1995. J. Neurosurg. 82, 635.
      Tamargo, R.J., et al. 1991. Cancer Res. 51, 672.