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475841 Miltefosine - CAS 58066-85-6 - Calbiochem

An ether lipid analog that acts as an inhibitor of CTP:phosphocholine cytidyltransferase and displays remarkable antiproliferative effect both in vitro and in vivo.

Miltefosine - CAS 58066-85-6 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: HePC, 1-Hexadecylphosphorylcholine

Primary Target: CTP:phosphocholine cytidyltransferase
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      Aperçu

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      58066-85-6C₂₁H₄₆NO₄P
      Description
      OverviewAn ether lipid analog that acts as an inhibitor of CTP:phosphocholine cytidyltransferase and displays remarkable antiproliferative effect both in vitro and in vivo. Also induces apoptosis mediated by cell-permeable ceramides.
      Catalogue Number475841
      Brand Family Calbiochem®
      SynonymsHePC, 1-Hexadecylphosphorylcholine
      References
      ReferencesWieder, T., et al. 1998. J. Biol. Chem. 273, 11025.
      Wieder, T., et al. 1993. Biochem. J. 291, 561.
      Geilen, C.C., et al. 1992. J. Biol. Chem. 267, 6719.
      Geilen, C.C., et al. 1991. Eur. J. Cancer 27, 1650.
      Product Information
      CAS number58066-85-6
      ATP CompetitiveN
      FormCrystalline solid
      Hill FormulaC₂₁H₄₆NO₄P
      Chemical formulaC₂₁H₄₆NO₄P
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetCTP:phosphocholine cytidyltransferase
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Safety Information according to GHS
      RTECSKH2890000
      Safety Information
      R PhraseR: 20/21/22-36/37/38

      Harmful by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 22-26-36

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution in ethanol or DMSO, aliquot and freeze (-20°C). Stock solutions in ethanol or DMSO are stable for up to 3 months at -20°C. Stock solutions in PBS are stable for up to 24 h at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Référence GTIN
      475841 0