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475815 Microcystin-LR, Microcystis aeruginosa - CAS 101043-37-2 - Calbiochem

Microcystin-LR, Microcystis aeruginosa - CAS 101043-37-2, is a potent inhibitor of protein phosphatase 1 (IC50 = 1.7 nM) and protein phosphatase 2A (IC50 = 40 pM).

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: MCYST-LR

Primary Target: PP1
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Tableau de caractéristiques principal

CAS #Empirical Formula
101043-37-2C₄₉H₇₄N₁₀O₁₂

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      Description
      OverviewCyclic heptapeptide toxin isolated from the freshwater cyanobacteria Microcystis aeruginosa. Potent inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A). Unlike Okadaic Acid (Cat. No. 495604), microcystin-LR is effective on both PP1 (IC50 = 1.7 nM) and PP2A (IC50 = 40 pM). Reacts with phosphatase in a two-step mechanism involving rapid binding and inactivation of the catalytic subunit followed by slower covalent interactions. Has no effect on protein kinases, making it useful for reducing the effect of contaminating phosphatase activities in protein kinase assays. A 2.5 mM (250 µg/100 µl) solution of Microcystin-LR, Microcystis aeruginosa (Cat. No. 475821) in DMSO is also available.
      Catalogue Number475815
      Brand Family Calbiochem®
      SynonymsMCYST-LR
      References
      ReferencesCraig, M., et al. 1996. Biochem. Cell Biol. 74, 569.
      Nishiwaki, R., et al. 1994. Cancer Lett. 83, 283.
      Amick, G.D., et al. 1992. Biochem. J. 287, 1019.
      Davidson, H.W., et al. 1992. J. Cell Biol. 116, 1343.
      Nishiwaki-Matsushima, R., et al. 1992. J. Cancer Res. Clin. Oncol. 118, 420.
      Cohen, P., et al. 1990. Trends Biochem. Sci. 15, 98.
      MacKintosh, C., et al. 1990. FEBS Lett. 264, 187.
      Cohen, P., et al. 1989. FEBS Lett. 250, 596.
      Carmichael, W.W. 1988. in Handbook of Natural Toxins 3: Marine Toxins and Venoms (Tu, A.T., Ed.) p. 121, Decker, New York.
      Product Information
      CAS number101043-37-2
      ATP CompetitiveN
      DeclarationNot available for sale outside of the United States.
      FormLyophilized pale-yellow solid
      Hill FormulaC₄₉H₇₄N₁₀O₁₂
      Chemical formulaC₄₉H₇₄N₁₀O₁₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationMicrocystin-LR, Microcystis aeruginosa - CAS 101043-37-2, is a potent inhibitor of protein phosphatase 1 (IC50 = 1.7 nM) and protein phosphatase 2A (IC50 = 40 pM).
      Biological Information
      Primary TargetPP1
      Primary Target IC<sub>50</sub>1.7 nM and 40 pM against PP1 and PP2A, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSGT2810000
      Safety Information
      R PhraseR: 26/27/28-36/37/38-43

      Very toxic by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      May cause sensitization by skin contact.
      S PhraseS: 26-36/37/39-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Unstable at > pH 7.7.
      End use certificateY
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      475815-500UG 04055977185591

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Microcystin-LR, Microcystis aeruginosa - CAS 101043-37-2 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Microcystin-LR, Microcystis aeruginosa - CAS 101043-37-2 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      475815

      Références bibliographiques

      Aperçu de la référence bibliographique
      Craig, M., et al. 1996. Biochem. Cell Biol. 74, 569.
      Nishiwaki, R., et al. 1994. Cancer Lett. 83, 283.
      Amick, G.D., et al. 1992. Biochem. J. 287, 1019.
      Davidson, H.W., et al. 1992. J. Cell Biol. 116, 1343.
      Nishiwaki-Matsushima, R., et al. 1992. J. Cancer Res. Clin. Oncol. 118, 420.
      Cohen, P., et al. 1990. Trends Biochem. Sci. 15, 98.
      MacKintosh, C., et al. 1990. FEBS Lett. 264, 187.
      Cohen, P., et al. 1989. FEBS Lett. 250, 596.
      Carmichael, W.W. 1988. in Handbook of Natural Toxins 3: Marine Toxins and Venoms (Tu, A.T., Ed.) p. 121, Decker, New York.

      Brochure

      Titre
      Protein Phosphatases Technical Bulletin
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-August-2008 RFH
      SynonymsMCYST-LR
      DescriptionCyclic heptapeptide toxin isolated from the freshwater cyanobacteria, Microcystis aeruginosa. Potent inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A). Unlike Okadaic Acid (Cat. No. 495604), microcystin-LR is effective on both PP1 (IC50 = 1.7 nM) and PP2A (IC50 = 40 pM). Has no effect on protein kinases, making it useful for reducing contaminating phosphatase activities in protein kinase assays.
      FormLyophilized pale-yellow solid
      CAS number101043-37-2
      RTECSGT2810000
      Chemical formulaC₄₉H₇₄N₁₀O₁₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (2.5 mg/ml) or Methanol (2 mg/ml). Further dilute with aqueous buffer just prior to use.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Unstable at > pH 7.7.
      Toxicity Highly Toxic
      ReferencesCraig, M., et al. 1996. Biochem. Cell Biol. 74, 569.
      Nishiwaki, R., et al. 1994. Cancer Lett. 83, 283.
      Amick, G.D., et al. 1992. Biochem. J. 287, 1019.
      Davidson, H.W., et al. 1992. J. Cell Biol. 116, 1343.
      Nishiwaki-Matsushima, R., et al. 1992. J. Cancer Res. Clin. Oncol. 118, 420.
      Cohen, P., et al. 1990. Trends Biochem. Sci. 15, 98.
      MacKintosh, C., et al. 1990. FEBS Lett. 264, 187.
      Cohen, P., et al. 1989. FEBS Lett. 250, 596.
      Carmichael, W.W. 1988. in Handbook of Natural Toxins 3: Marine Toxins and Venoms (Tu, A.T., Ed.) p. 121, Decker, New York.