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454126 Methotrexate - CAS 59-05-2 - Calbiochem

Methotrexate - CAS 59-05-2 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
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454126
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
59-05-2C₂₀H₂₂N₈O₅ • 3H₂O

Prix & Disponibilité

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454126-100MG
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      		 Flacon en verre 100 mg
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      Description
      OverviewInhibits thymidylate synthetase, is a nonselective de novo purine synthesis inhibitor, and has a significant toxicity profile including hepatotoxicity, pneumonitis, and bone marrow suppression. Potent folic acid antagonist. Induces apoptosis in HL-60 human leukemia cells. Also useful as an antitumor agent.
      Catalogue Number454126
      Brand Family Calbiochem®
      References
      ReferencesKaufman, S.H., et al. 1993. Cancer Res. 53, 3976.
      Takasuga, A., et al. 1992. J. Biochem. 112, 652.
      Hirata, S., et al. 1989. Arthritis Rheum. 32, 1065.
      Jolivet, J., et al. 1983. New Engl. J. Med. 309, 1094.
      Product Information
      CAS number59-05-2
      FormYellow solid
      Hill FormulaC₂₀H₂₂N₈O₅ • 3H₂O
      Chemical formulaC₂₀H₂₂N₈O₅ • 3H₂O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 23/24/25-36/37/38-45-46

      Toxic by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      May cause cancer.
      May cause heritable genetic damage.
      S PhraseS: 22-24/25-36/37/39

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing, gloves and eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      454126-100MG 04055977204711

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Methotrexate - CAS 59-05-2 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Methotrexate - CAS 59-05-2 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      454126

      Références bibliographiques

      Aperçu de la référence bibliographique
      Kaufman, S.H., et al. 1993. Cancer Res. 53, 3976.
      Takasuga, A., et al. 1992. J. Biochem. 112, 652.
      Hirata, S., et al. 1989. Arthritis Rheum. 32, 1065.
      Jolivet, J., et al. 1983. New Engl. J. Med. 309, 1094.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-October-2010 RFH
      DescriptionInhibits thymidylate synthetase, is a nonselective de novo purine synthesis inhibitor and has a significant toxicity profile including hepatotoxicity, pneumonitis and bone marrow suppression. Potent folic acid antagonist. Induces apoptosis in HL-60 human leukemia cells. Also useful as an anti-tumor agent.
      FormYellow solid
      CAS number59-05-2
      Chemical formulaC₂₀H₂₂N₈O₅ • 3H₂O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Toxic
      Merck USA index14, 5985
      ReferencesKaufman, S.H., et al. 1993. Cancer Res. 53, 3976.
      Takasuga, A., et al. 1992. J. Biochem. 112, 652.
      Hirata, S., et al. 1989. Arthritis Rheum. 32, 1065.
      Jolivet, J., et al. 1983. New Engl. J. Med. 309, 1094.