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505207 Mecamylamine Hydrochloride - CAS 826-39-1 - Calbiochem

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Synonymes: N,2,3,3-Tetramethylbicyclo[2.2.1]he­ptan-2-amine hydrochloride, TC-5214, Inversine, nAChR Antagonist, Mecamylamine hydrochloride

Primary Target: nAChR
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505207
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Tableau de caractéristiques principal

CAS #Empirical Formula
826-39-1C₁₁H₂₁N•HCl

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      Description
      OverviewA potent, nonselective, and noncompetitive antagonist of nAChRs (IC50 = 640 nM, 2.5 µM, 3.6 µM and 6.9 µM for α3β4, α4β2, α3β2 and α7 subtype nAChRs, respectively). Biologically viable admitted orally or systematically. Widely used in investigating the roles of central nAChRs in the brain functions (learning and memory, decision making, cognition) and disorders (addiction, Autisms, Tourette's syndrome, Schizophrenia and various cognitive and mood disorders).
      Catalogue Number505207
      Brand Family Calbiochem®
      SynonymsN,2,3,3-Tetramethylbicyclo[2.2.1]he­ptan-2-amine hydrochloride, TC-5214, Inversine, nAChR Antagonist, Mecamylamine hydrochloride
      References
      ReferencesHarris, C., et al. 2013. Psychopharmacol. 225, 291.
      Lima, H., et al. 2013. Learning & Memory 20, 120.
      Arnold, E., et al. 2012. J. Child Adolesc. Psychopharmacol. 22, 198.
      Bacher, I., et al. 2009. Expert Opin. Pharmacother. 10, 2709.
      Lippiello, M., et al. 2008. CNS Neurosci. Ther. 14, 266.br>J. M. Young et al. 2001. Clin. Ther. 23, 532.
      Product Information
      CAS number826-39-1
      FormOff-white solid
      Hill FormulaC₁₁H₂₁N•HCl
      Chemical formulaC₁₁H₂₁N•HCl
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetnAChR
      Primary Target IC<sub>50</sub>640 nM
      Purity≥98% by TLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 25-36/37/38

      Toxic if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 22-26-28.1-36/37/39-46-63

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      After contact with skin, wash immediately with plenty of water.
      Wear suitable protective clothing, gloves and eye/face protection.
      If swallowed, seek medical advice immediately and show this container or label.
      In case of accident by inhalation: remove casualty to fresh air and keep at rest.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      5.05207.0001 04055977263435

      Documentation

      Mecamylamine Hydrochloride - CAS 826-39-1 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Mecamylamine Hydrochloride - CAS 826-39-1 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      505207

      Références bibliographiques

      Aperçu de la référence bibliographique
      Harris, C., et al. 2013. Psychopharmacol. 225, 291.
      Lima, H., et al. 2013. Learning & Memory 20, 120.
      Arnold, E., et al. 2012. J. Child Adolesc. Psychopharmacol. 22, 198.
      Bacher, I., et al. 2009. Expert Opin. Pharmacother. 10, 2709.
      Lippiello, M., et al. 2008. CNS Neurosci. Ther. 14, 266.br>J. M. Young et al. 2001. Clin. Ther. 23, 532.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-July-2013 JSW
      SynonymsN,2,3,3-Tetramethylbicyclo[2.2.1]he­ptan-2-amine hydrochloride, TC-5214, Inversine, nAChR Antagonist, Mecamylamine hydrochloride
      DescriptionA potent, nonselective, and noncompetitive antagonist of nAChRs (IC50 = 640 nM, 2.5 µM, 3.6 µM and 6.9 µM for α3β4, α4β2, α3β2 and α7 subtype nAChRs, respectively). Biologically viable admitted orally or systematically. Widely used in investigating the roles of central nAChRs in the brain functions (learning and memory, decision making, cognition) and disorders (addiction, Autisms, Tourette's syndrome, Schizophrenia and various cognitive and mood disorders).
      FormOff-white solid
      CAS number826-39-1
      Chemical formulaC₁₁H₂₁N•HCl
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityH₂O (100 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Toxic
      ReferencesHarris, C., et al. 2013. Psychopharmacol. 225, 291.
      Lima, H., et al. 2013. Learning & Memory 20, 120.
      Arnold, E., et al. 2012. J. Child Adolesc. Psychopharmacol. 22, 198.
      Bacher, I., et al. 2009. Expert Opin. Pharmacother. 10, 2709.
      Lippiello, M., et al. 2008. CNS Neurosci. Ther. 14, 266.br>J. M. Young et al. 2001. Clin. Ther. 23, 532.