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504685 LY 354740 - CAS 176199-48-7 - Calbiochem

LY 354740 - CAS 176199-48-7 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxy lic acid, Eglumegad, Eglumetad

Primary Target: mGlu2/3 receptors
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      176199-48-7C₈H₁₁NO₄
      Description
      Overview

      This product has been discontinued.



      A highly potent agonist selective for group II (mGluR2/3) receptors (EC50 = 5.1 and 24.3 nM at mGlu2 and mGlu3 receptors respectively), No effect at other mGlu subtype receptors (mGlu1a, mGlu5a, mGlu4 or mGlu7) at concentration less than 100 µM. Biologically viable admitted orally or systematically. Widely used in studies of addiction, epilepsy, schizophrenia, hyperactivity, and sleep.
      Catalogue Number504685
      Brand Family Calbiochem®
      Synonyms(1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxy lic acid, Eglumegad, Eglumetad
      References
      ReferencesSiok, J., et al. 2012. Neuropharmacol. 62, 226.
      Fell, J., et al. 2012. Neuropharmacol. 62, 1473.
      Pilc, A., 2003. IDrugs. 6, 71.
      Klodzinska. A., 1999. Neuropharmacol. 38, 1831.
      Monn, J., 1997. J. Med. Chem. 40, 528.
      Schoepp, D., 1997. Neuropharmacol. 36, 1.
      Bond, A., 1997. Neuroreport. 8, 1463.
      Product Information
      CAS number176199-48-7
      FormWhite solid
      Hill FormulaC₈H₁₁NO₄
      Chemical formulaC₈H₁₁NO₄
      Sold on the basis of peptide contentY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetmGlu2/3 receptors
      Purity≥99% by HPLC
      Physicochemical Information
      Peptide ContentY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 22

      Harmful if swallowed.
      S PhraseS: 22-24/25-36/37/39

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing, gloves and eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      504685 0

      Documentation

      LY 354740 - CAS 176199-48-7 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Siok, J., et al. 2012. Neuropharmacol. 62, 226.
      Fell, J., et al. 2012. Neuropharmacol. 62, 1473.
      Pilc, A., 2003. IDrugs. 6, 71.
      Klodzinska. A., 1999. Neuropharmacol. 38, 1831.
      Monn, J., 1997. J. Med. Chem. 40, 528.
      Schoepp, D., 1997. Neuropharmacol. 36, 1.
      Bond, A., 1997. Neuroreport. 8, 1463.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-July-2013 JSW
      Synonyms(1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxy lic acid, Eglumegad, Eglumetad
      DescriptionA highly potent agonist selective for group II (mGluR2/3) receptors (EC50 = 5.1 and 24.3 nM at mGlu2 and mGlu3 receptors respectively), No effect at other mGlu subtype receptors (mGlu1a, mGlu5a, mGlu4 or mGlu7) at concentration less than 100 µM. Biologically viable admitted orally or systematically. Widely used in studies of addiction, epilepsy, schizophrenia, hyperactivity, and sleep.
      FormWhite solid
      CAS number176199-48-7
      Chemical formulaC₈H₁₁NO₄
      Structure formulaStructure formula
      Purity≥99% by HPLC
      Solubility1N NaOH (100 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesSiok, J., et al. 2012. Neuropharmacol. 62, 226.
      Fell, J., et al. 2012. Neuropharmacol. 62, 1473.
      Pilc, A., 2003. IDrugs. 6, 71.
      Klodzinska. A., 1999. Neuropharmacol. 38, 1831.
      Monn, J., 1997. J. Med. Chem. 40, 528.
      Schoepp, D., 1997. Neuropharmacol. 36, 1.
      Bond, A., 1997. Neuroreport. 8, 1463.