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420600 Ketoconazole - CAS 65277-42-1 - Calbiochem

An inhibitor of cytochrome P-450 in steroid biosynthesis. An antifungal agent that displays potent anti-metastatic, anti-neoplastic, and anti-psoriatic activities.

Ketoconazole - CAS 65277-42-1 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, R-41400, CYP17A1 Inhibitor I

Primary Target: 5-LO
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420600
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Tableau de caractéristiques principal

CAS #Empirical Formula
65277-42-1C₂₆H₂₈Cl₂N₄O₄

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420600-50MG
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      Description
      OverviewAn inhibitor of cytochrome P-450 in steroid biosynthesis. An antifungal agent that displays potent anti-metastatic, anti-neoplastic, and anti-psoriatic activities. Also acts as an inhibitor of 5-lipoxygenase (5-LO; IC50 = 26 µM) and thromboxane synthase activities.
      Catalogue Number420600
      Brand Family Calbiochem®
      Synonymscis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, R-41400, CYP17A1 Inhibitor I
      References
      Referencesvan Wauwe, J.P., and Janssen, P.A.J. 1989. J. Med. Chem. 32, 2231.
      Beetens, J.R., et al. 1986. Biochem. Pharmacol. 35, 883.
      Lambert, A., et al. 1986. Biochem. Pharmacol. 35, 3999.
      Tucker, W.F.G., and MacNeil, S. 1986. Br. Med. J. 293, 882.
      Lelcuk, S., et al. 1984. J. Trauma 24, 393.
      Product Information
      CAS number65277-42-1
      FormOff-white solid
      Hill FormulaC₂₆H₂₈Cl₂N₄O₄
      Chemical formulaC₂₆H₂₈Cl₂N₄O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary Target5-LO
      Primary Target IC<sub>50</sub>26 µM
      Purity≥98% by HPLC
      Safety Information according to GHS
      RTECSTK7912300
      Safety Information
      R PhraseR: 25-40-63-36/37/38

      Toxic if swallowed.
      Limited evidence of a carcinogenic effect.
      Possible risk of harm to the unborn child.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 22-26-36

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Global Trade Item Number
      Référence GTIN
      420600-50MG 04055977187618