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422711 KN-93, Water-Soluble - Calbiochem

This KN-93 is a water-soluble version of KN-93 that acts as a reversible and competitive inhibitor of CaM kinase II (Ki = 370 nM for rat brain).

KN-93, Water-Soluble - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Primary Target: Calmodulin-Dependent Protein Kinase (CaM Kinase) 2
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422711
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Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₂₆H₂₉ClN₂O₄S · H₃PO₄

Prix & Disponibilité

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422711-1MG
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      Description
      OverviewA water-soluble form of the CaM kinase II inhibitor KN-93 (Cat. No. 422708). Also available as a 5 mM solution in H2(Cat. No. 508315).
      Catalogue Number422711
      Brand Family Calbiochem®
      References
      ReferencesTombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
      Chen, C., et al. 1994. Science 266, 291.
      Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
      Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
      Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
      Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₆H₂₉ClN₂O₄S · H₃PO₄
      Chemical formulaC₂₆H₂₉ClN₂O₄S · H₃PO₄
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCalmodulin-Dependent Protein Kinase (CaM Kinase) 2
      Primary Target K<sub>i</sub>370 nM for cam kinase 2
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      422711-1MG 04055977187274

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      KN-93, Water-Soluble - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      KN-93, Water-Soluble - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      422711

      Références bibliographiques

      Aperçu de la référence bibliographique
      Tombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
      Chen, C., et al. 1994. Science 266, 291.
      Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
      Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
      Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
      Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-August-2008 RFH
      DescriptionA water-soluble form of the CaM kinase II inhibitor KN-93 (Cat. No. 422708). Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Has no significant effect on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.
      FormWhite solid
      Chemical formulaC₂₆H₂₉ClN₂O₄S · H₃PO₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityH₂O (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesTombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
      Chen, C., et al. 1994. Science 266, 291.
      Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
      Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
      Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
      Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.

      Produits & Applications associés

      Alternative Products

      Référence Description  
      422708 KN-93 - CAS 139298-40-1 - Calbiochem Prix & Disponibilité

      Catégories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Calmodulin-Dependent Protein Kinase (CaM Kinase) Inhibitors