420298 Sigma-AldrichK-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem
K-252a, Nocardiopsis sp., CAS 97161-97-2, is a cell-permeable, ATP-competitive inhibitor of multiple protein kinases (Ki = 1.8, 20, 18, 25, 20, 3 nM for CaMKII, MLCK, PKA, PKC, PKG & 140 trk).
More>> K-252a, Nocardiopsis sp., CAS 97161-97-2, is a cell-permeable, ATP-competitive inhibitor of multiple protein kinases (Ki = 1.8, 20, 18, 25, 20, 3 nM for CaMKII, MLCK, PKA, PKC, PKG & 140 trk). Less<<Produits recommandés
Aperçu
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Tableau de caractéristiques principal
CAS # | Empirical Formula |
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97161-97-2 | C₂₇H₂₁N₃O₅ |
Prix & Disponibilité
Référence | Disponibilité | Conditionnement | Qté | Prix | Quantité | |
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420298-100UG |
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Ampoule plast. | 100 μg |
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Description | |
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Overview | A cell-permeable, reversible, and ATP-competitive inhibitor against multiple protein kinases, including, but not limited to, CaM kinase II (Ki = 1.8 nM), myosin light chain kinase (Ki = 20 nM), protein kinase A (Ki = 18 nM), protein kinase C (Ki = 25 nM), protein kinase G (Ki = 20 nM), NGF receptor gp140trk (IC50 = 3 nM), its transforming trk oncogenes, and the related neurotrophin receptors gp145trkB and gp145trkC. Reported to induce apoptosis and cell cycle arrest by decreasing Cdk1 and Cdc25c activity in T98G cells and inhibit Flt3 phosphorylation in Flt3/Itd-BaF3 cells (IC50 <50 nM). Also available as a premade 1 mM (100 µg/214 µl) solution in DMSO (Cat. No. 420297). |
Catalogue Number | 420298 |
Brand Family | Calbiochem® |
Product Information | |
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CAS number | 97161-97-2 |
ATP Competitive | Y |
Form | White solid |
Hill Formula | C₂₇H₂₁N₃O₅ |
Chemical formula | C₂₇H₂₁N₃O₅ |
Reversible | Y |
Structure formula Image | |
Quality Level | MQ100 |
Physicochemical Information | |
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Cell permeable | Y |
Dimensions |
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Materials Information |
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Toxicological Information |
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Safety Information according to GHS | |
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RTECS | NZ0550000 |
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Supplemental Information |
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Specifications |
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Global Trade Item Number | |
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Référence | GTIN |
420298-100UG | 04055977210910 |
Documentation
Required Licenses
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PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD |
K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem FDS
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K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem Certificats d'analyse
Titre | Numéro de lot |
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420298 |
Références bibliographiques
Aperçu de la référence bibliographique |
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Cools, J., et al. 2004. Cancer Res. 64, 6385. Chin, L.S., et al. 1999. Cancer Invest. 17, 391. Tapley, P., et al. 1992. Oncogene 7, 371. Hashimoto, Y. 1991. Biochem. Biophys. Res. Commun. 181, 423. Nakanishi, S. 1988. J. Biol. Chem. 263, 6215. Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436. |
Citations
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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