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407272 Integrin αvβ3 Antagonist, P11 - Calbiochem

The Integrin αvβ3 Antagonist, P11 controls the biological activity of Integrin αvβ3.

Integrin αvβ3 Antagonist, P11 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: HSDVHK-NH2, HSDVHK

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407272
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Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₃₀H₅₁N₁₂O₉₃· 3TFA

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407272-5MG
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      Description
      OverviewA cell-permeable, hexapeptide containing a novel integrin-binding motif, SDV (a Type I PDZ-binding motif) that is shown to compete with vitronectin for the RGD-binding site of integrin αvβ3 (IC50 = 1.74 pg/ml), in a chip-based assay. It is rapidly internalized into HUVECs, but not in NIH 3T3 cells, at a culture temperature of 37 °C, a process which is mediated by caveolin and clathrin. At 10 µg/ml, this compound is shown to significantly inhibit the phosphorylation of ERK1/2 and MEK in HUVECs. Furthermore, it suppresses bFGF-induced proliferation of HUVECs, dose-dependently, and displays up-regulation of p53 and induction of apoptosis via activation of caspases-3, -8 and -9 at 50 µg/ml.
      Catalogue Number407272
      Brand Family Calbiochem®
      SynonymsHSDVHK-NH2, HSDVHK
      References
      ReferencesBang, J., et al. 2011. Mol Cell Proteomics 10, M110.
      Choi, Y., et al. 2010. Proteomics 10, 72.
      Lee, Y., et al. 2004. J. Biomol. Screen. 9, 687.
      Product Information
      FormWhite solid
      FormulationSupplied as a trifluoracetate salt.
      Hill FormulaC₃₀H₅₁N₁₂O₉₃· 3TFA
      Chemical formulaC₃₀H₅₁N₁₂O₉₃· 3TFA
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      407272-5MG 04055977188769

      Documentation

      Integrin αvβ3 Antagonist, P11 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Integrin αvβ3 Antagonist, P11 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      407272

      Références bibliographiques

      Aperçu de la référence bibliographique
      Bang, J., et al. 2011. Mol Cell Proteomics 10, M110.
      Choi, Y., et al. 2010. Proteomics 10, 72.
      Lee, Y., et al. 2004. J. Biomol. Screen. 9, 687.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-jul-2012
      SynonymsHSDVHK-NH2, HSDVHK
      DescriptionA cell-permeable, hexapeptide containing a novel integrin-binding motif, SDV (a Type I PDZ-binding motif) that is shown to compete with vitronectin for the RGD-binding site of integrin αvβ3 (IC50 = 1.74 pg/ml), in a chip-based assay. It is rapidly internalized into HUVECs, but not in NIH 3T3 cells, at a culture temperature of 37 °C, a process which is mediated by caveolin and clathrin. At 10 µg/ml, this compound is shown to significantly inhibit the phosphorylation of ERK1/2 and MEK in HUVECs. Furthermore, it suppresses bFGF-induced proliferation of HUVECs, dose-dependently, and displays up-regulation of p53 and induction of apoptosis via activation of caspases-3, -8 and -9 at 50 µg/ml.
      FormWhite solid
      FormulationSupplied as a trifluoracetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₀H₅₁N₁₂O₉₃· 3TFA
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityH₂O (100 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBang, J., et al. 2011. Mol Cell Proteomics 10, M110.
      Choi, Y., et al. 2010. Proteomics 10, 72.
      Lee, Y., et al. 2004. J. Biomol. Screen. 9, 687.