Millipore Sigma Vibrant Logo

402086 Indirubin-3ʹ-monoxime, 5-Iodo- - CAS 331467-03-9 - Calbiochem

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Primary Target: Gsk-3β
View Products on Sigmaaldrich.com
402086
  
Prix en cours de récupération
Le prix n'a pas pu être récupéré
La quantité minimale doit être un multiple de
Maximum Quantity is
À la validation de la commande Plus d'informations
Vous avez sauvegardé ()
 
—
Demander le prix
—
Disponibilité limitée Disponibilité limitée
En stock 
Interrompu(e)
Disponible en quantités limitées
Disponibilité à confirmer
    Pour le restant : Nous vous tiendrons informé
      Pour le restant : Nous vous tiendrons informé
      Nous vous tiendrons informé
      Contacter le Service Clients
      Contact Customer Service

       

      Contacter le Service Clients

      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      331467-03-9C₁₆H₁₀IN₃O₂
      Description
      Overview

      This product has been discontinued.



      A highly potent cell-permeable and reversible inhibitor of glycogen synthase kinase-3β (GSK-3β; IC50 = 9 nM). Also inhibits Cdk1 (IC50 = 25 nM) and Cdk5 (IC50 = 20 nM) activities. Acts by binding to the ATP-binding pocket of these enzymes.
      Catalogue Number402086
      Brand Family Calbiochem®
      References
      ReferencesLeclerc, S., et al. 2001. J. Biol. Chem. 276, 251.
      Hoessel, R., et al. 1999. Nat. Cell Biol. 1, 60.
      Product Information
      CAS number331467-03-9
      ATP CompetitiveY
      FormDark red solid
      Hill FormulaC₁₆H₁₀IN₃O₂
      Chemical formulaC₁₆H₁₀IN₃O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGsk-3β
      Primary Target IC<sub>50</sub>9 nM against GSK-3β
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      402086 0

      Documentation

      Indirubin-3ʹ-monoxime, 5-Iodo- - CAS 331467-03-9 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Indirubin-3ʹ-monoxime, 5-Iodo- - CAS 331467-03-9 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      402086

      Références bibliographiques

      Aperçu de la référence bibliographique
      Leclerc, S., et al. 2001. J. Biol. Chem. 276, 251.
      Hoessel, R., et al. 1999. Nat. Cell Biol. 1, 60.

      Brochure

      Titre
      Alzheimer's Disease Brochure & Technical Guide
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      DescriptionA highly potent, cell-permeable, and reversible inhibitor of glycogen synthase kinase-3β (GSK-3β) (IC50 = 9 nM). Reported to inhibit GSK-3β phosphorylation of human tau protein in vitro (IC50 ~100 nM) and in cells (effective concentration = 20 µM). Also inhibits CDK1 (IC50 = 25 nM) and CDK5 (IC50 = 20 nM). Shown to inhibit phosphorylation of DARPP-32 by CDK5 in brain sections enriched for DARPP-32. Inhibition is competitive with respect to ATP.
      FormDark red solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number331467-03-9
      Chemical formulaC₁₆H₁₀IN₃O₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesLeclerc, S., et al. 2001. J. Biol. Chem. 276, 251.
      Hoessel, R., et al. 1999. Nat. Cell Biol. 1, 60.