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508158 InSolution™ TGF-β RI Kinase Inhibitor II, RepSox - CAS 446859-33-2 - Calbiochem

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Synonymes: 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine, RepSox InSolution, E-616452 InSolution, ALK5 Inhibitor II, Transforming Growth Factor-β, Type I Receptor Kinase Inhibitor II

Primary Target: ALK5
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508158
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Tableau de caractéristiques principal

CAS #Empirical Formula
446859-33-2C₁₇H₁₃N₅

Prix & Disponibilité

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5.08158.0001
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      Description
      Catalogue Number508158
      Brand Family Calbiochem®
      Synonyms2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine, RepSox InSolution, E-616452 InSolution, ALK5 Inhibitor II, Transforming Growth Factor-β, Type I Receptor Kinase Inhibitor II
      References
      ReferencesIchida, J. K., et al. 2009. Cell Stem Cell 5, 491.
      Gellibert, F., et al. 2004. J. Med. Chem. 47, 4494.
      Product Information
      CAS number446859-33-2
      FormLiquid
      FormulationA 50 mM (5 mg/348 µl) sterile-filtered solution of TGF-β RI Kinase Inhibitor II, RepSox (Cat. No. 616452) in DMSO.
      Hill FormulaC₁₇H₁₃N₅
      Chemical formulaC₁₇H₁₃N₅
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetALK5
      Primary Target IC<sub>50</sub>23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation, and TGF-&beta
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only fresh DMSO for further dilution.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      5.08158.0001 04055977242904

      Documentation

      InSolution™ TGF-β RI Kinase Inhibitor II, RepSox - CAS 446859-33-2 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Ichida, J. K., et al. 2009. Cell Stem Cell 5, 491.
      Gellibert, F., et al. 2004. J. Med. Chem. 47, 4494.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-December-2013 JSW
      Synonyms2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine, RepSox InSolution, E-616452 InSolution, ALK5 Inhibitor II, Transforming Growth Factor-β, Type I Receptor Kinase Inhibitor II
      DescriptionA cell-permeable, potent, selective, reversible, and ATP-competitive inhibitor of TGF-β type I receptor (ALK5; IC50 = 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation, and TGF-β cellular assay in HepG2 cells, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK (IC50 >16 µM).
      FormLiquid
      FormulationA 50 mM (5 mg/348 µl) sterile-filtered solution of TGF-β RI Kinase Inhibitor II, RepSox (Cat. No. 616452) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number446859-33-2
      Chemical formulaC₁₇H₁₃N₅
      Structure formulaStructure formula
      Purity≥99% by HPLC
      Storage Protect from light
      Avoid freeze/thaw
      ≤ -70°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only fresh DMSO for further dilution.
      Toxicity Standard Handling
      ReferencesIchida, J. K., et al. 2009. Cell Stem Cell 5, 491.
      Gellibert, F., et al. 2004. J. Med. Chem. 47, 4494.