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239765 InSolution™ Cycloheximide - CAS 66-81-9 - Calbiochem

InSolution™ Cycloheximide, CAS 66-81-9, is a 100 mg/ml, sterile-filtered solution of Cycloheximide (Cat. No. 239763) in DMSO. An antifungal antibiotic that inhibits protein synthesis in eukaryotes.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Primary Target: hFKBP12
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      66-81-9C₁₅H₂₃NO₄
      Description
      Catalogue Number239765
      Brand Family Calbiochem®
      References
      ReferencesChristner, C., et al. 1999. J. Med. Chem. 42, 3615.
      Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys. 334, 175.
      Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
      Waring, P. 1990. J. Biol. Chem. 265, 14476.
      Obrig, T.G., et al. 1971. J. Biol. Chem. 246, 174.
      Pestka, S. 1971. Annu. Rev. Microbiol. 25, 487.
      Product Information
      CAS number66-81-9
      FormLiquid
      FormulationA 100 mg/ml solution of Cycloheximide (Cat. No. 239763) in DMSO (sterile-filtered).
      Hill FormulaC₁₅H₂₃NO₄
      Chemical formulaC₁₅H₂₃NO₄
      Quality LevelMQ100
      Applications
      ApplicationInSolution™ Cycloheximide, CAS 66-81-9, is a 100 mg/ml, sterile-filtered solution of Cycloheximide (Cat. No. 239763) in DMSO. An antifungal antibiotic that inhibits protein synthesis in eukaryotes.
      Biological Information
      Primary TargethFKBP12
      Primary Target K<sub>i</sub>3.4 µM
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSMA4375000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      239765 0

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      InSolution™ Cycloheximide - CAS 66-81-9 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      InSolution™ Cycloheximide - CAS 66-81-9 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      239765

      Références bibliographiques

      Aperçu de la référence bibliographique
      Christner, C., et al. 1999. J. Med. Chem. 42, 3615.
      Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys. 334, 175.
      Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
      Waring, P. 1990. J. Biol. Chem. 265, 14476.
      Obrig, T.G., et al. 1971. J. Biol. Chem. 246, 174.
      Pestka, S. 1971. Annu. Rev. Microbiol. 25, 487.

      Citations

      Titre
    • Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.
      		•
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-June-2008 RFH
      DescriptionA convenient ready-to-use form of Cycloheximide (Cat. No. 239763). An anti-fungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Also inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFKBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt's lymphoma cells, and a variety of other cell types, including rodent macrophages. Induces DNA fragmentation in macrophages, but inhibits DNA cleavage in rat thymocytes treated with thapsigargin, methylprednisolone, and ionomycin. Rapidly destroyed in alkaline solutions.
      FormLiquid
      FormulationA 100 mg/ml solution of Cycloheximide (Cat. No. 239763) in DMSO (sterile-filtered).
      Intert gas (Yes/No) Packaged under inert gas
      CAS number66-81-9
      RTECSMA4375000
      Chemical formulaC₁₅H₂₃NO₄
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      ReferencesChristner, C., et al. 1999. J. Med. Chem. 42, 3615.
      Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys. 334, 175.
      Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
      Waring, P. 1990. J. Biol. Chem. 265, 14476.
      Obrig, T.G., et al. 1971. J. Biol. Chem. 246, 174.
      Pestka, S. 1971. Annu. Rev. Microbiol. 25, 487.
      Citation
    • Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.
      		•