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508408 InSolution™ Batimastat - CAS 130370-60-4 - Calbiochem

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: (4-N-Hydroxyamino)-2R-isobutyl-3S-(thienylthiomethyl)succinyl)-L-phenylalanine-N-methylamide

Primary Target: MMPs
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508408
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Tableau de caractéristiques principal

CAS #Empirical Formula
130370-60-4C₂₃H₃₁N₃O₄S₂

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      Description
      Catalogue Number508408
      Brand Family Calbiochem®
      Synonyms(4-N-Hydroxyamino)-2R-isobutyl-3S-(thienylthiomethyl)succinyl)-L-phenylalanine-N-methylamide
      References
      ReferencesSchlomann, U., et al. 2002. J. Biol. Chem. 277, 48210.
      Whittaker, M., et al. 1999. Chem. Rev. 99, 2735.
      Parvathy, S., et al. 1998. Biochemistry 37, 1680.
      Parvathy, S., et al. 1998. FEBS Lett. 431, 63.
      Yamamoto, M., et al. 1998. J. Med. Chem. 41, 1209.
      Moss, M.L., et al. 1997. Nature 385, 733.
      Eccles, S.A., et al. 1996. Cancer Res. 56, 2815.
      Brown, P.D. 1995. Advan. Enzyme Regul. 35, 293.
      Wang, X., et al. 1994. Cancer Res. 54, 4726.
      Davies, B., et al. 1993. Cancer Res. 53, 2087.
      Product Information
      CAS number130370-60-4
      FormLiquid
      FormulationA 25 mM (2 mg/168 µL) sterile-filtered solution of Batimastat (Cat. No. 196440) in DMSO.
      Hill FormulaC₂₃H₃₁N₃O₄S₂
      Chemical formulaC₂₃H₃₁N₃O₄S₂
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMMPs
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only fresh DMSO for further dilutions.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      5.08408.0001 04055977261929

      Documentation

      InSolution™ Batimastat - CAS 130370-60-4 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Schlomann, U., et al. 2002. J. Biol. Chem. 277, 48210.
      Whittaker, M., et al. 1999. Chem. Rev. 99, 2735.
      Parvathy, S., et al. 1998. Biochemistry 37, 1680.
      Parvathy, S., et al. 1998. FEBS Lett. 431, 63.
      Yamamoto, M., et al. 1998. J. Med. Chem. 41, 1209.
      Moss, M.L., et al. 1997. Nature 385, 733.
      Eccles, S.A., et al. 1996. Cancer Res. 56, 2815.
      Brown, P.D. 1995. Advan. Enzyme Regul. 35, 293.
      Wang, X., et al. 1994. Cancer Res. 54, 4726.
      Davies, B., et al. 1993. Cancer Res. 53, 2087.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-December-2013 JSW
      Synonyms(4-N-Hydroxyamino)-2R-isobutyl-3S-(thienylthiomethyl)succinyl)-L-phenylalanine-N-methylamide
      DescriptionA Marimastat (Cat. No. 444289) type of peptidyl hydroxamate-based inhibitor that potently inhibits a broad-spectrum of metalloproteinases, including MMP-1, MMP-2, MMP-3/stromelysin, MMP-7/matrilysin, MMP-9, ΔMT1 (MMP-14 without TM domain), ADAM8, and ADAM17/TACE (IC50 = 3, 4, 20, 6, 4, 2.08, 51.3, and 19 nM, respectively), by targeting both the substrate binding site and the active-site Zn2+, while being much less potent toward ACE (Angiotensin Converting Enzyme) or α-secretase (IC50 = 1.6 and 3.3 µM, respectively). Batimastat is widely used in studying the involvement of MMPs in cancinogenesis and non-cancer pathological processes both in cultures in vitro and in animals in vivo.
      FormLiquid
      FormulationA 25 mM (2 mg/168 µL) sterile-filtered solution of Batimastat (Cat. No. 196440) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number130370-60-4
      Chemical formulaC₂₃H₃₁N₃O₄S₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      Storage Protect from light
      Avoid freeze/thaw
      ≤ -70°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only fresh DMSO for further dilutions.
      Toxicity Standard Handling
      ReferencesSchlomann, U., et al. 2002. J. Biol. Chem. 277, 48210.
      Whittaker, M., et al. 1999. Chem. Rev. 99, 2735.
      Parvathy, S., et al. 1998. Biochemistry 37, 1680.
      Parvathy, S., et al. 1998. FEBS Lett. 431, 63.
      Yamamoto, M., et al. 1998. J. Med. Chem. 41, 1209.
      Moss, M.L., et al. 1997. Nature 385, 733.
      Eccles, S.A., et al. 1996. Cancer Res. 56, 2815.
      Brown, P.D. 1995. Advan. Enzyme Regul. 35, 293.
      Wang, X., et al. 1994. Cancer Res. 54, 4726.
      Davies, B., et al. 1993. Cancer Res. 53, 2087.