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401493 IKK Inhibitor XIII, 17-AJB - Calbiochem

The IKK Inhibitor XIII, 17-AJB controls the biological activity of IKK. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

IKK Inhibitor XIII, 17-AJB - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
401493
  
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical Formula
      C₂₂H₂₈O₆
      Description
      Overview

      This product has been discontinued.



      A cell-permeable herbal-derived jolkinolide that acts as an irreversible inhibitor against IKK-β activity (IC50 = 300 nM). 17-AJB at 10 µM is shown to completely suppress TNF-α-induced IκB-α phosphosphorylation/degradation and NF-κB transcription activity in HepG2 cultures, as well as NF-κB p65 nuclear translocation in A549 cells. Reported to inhibit the growth of several cancer cell lines, including U937, Jurkat, and CoLo205 (IC50 = 0.74, 1.06, and 2.34 µM, respectively).
      Catalogue Number401493
      Brand Family Calbiochem®
      References
      ReferencesYan, S., et al. 2008. Mol. Cancer Ther. 7, 1523.
      Product Information
      FormOff white solid
      Hill FormulaC₂₂H₂₈O₆
      Chemical formulaC₂₂H₂₈O₆
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity>95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      401493 0

      Documentation

      IKK Inhibitor XIII, 17-AJB - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      IKK Inhibitor XIII, 17-AJB - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      401493

      Références bibliographiques

      Aperçu de la référence bibliographique
      Yan, S., et al. 2008. Mol. Cancer Ther. 7, 1523.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-August-2010 RFH
      DescriptionA cell-permeable herbal-derived jolkinolide that acts as an irreversible inhibitor against IKK-β activity (IC50 = 300 nM). 17-AJB at 10 µM is shown to completely suppress TNF-α-induced IκB-α phosphosphorylation/degradation and NF-κB transcription activity in HepG2 cultures, as well as NF-κB p65 nuclear translocation in A549 cells. Reported to inhibit the growth of several cancer cell lines, including U937, Jurkat, and CoLo205 (ICsub>50 = 0.74, 1.06, and 2.34 µM, respectively).
      FormOff white solid
      Chemical formulaC₂₂H₂₈O₆
      Structure formulaStructure formula
      Purity>95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesYan, S., et al. 2008. Mol. Cancer Ther. 7, 1523.