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508506 Gabapentin - CAS 60142-96-3 - Calbiochem

A water soluble GABA analog that interacts with voltage-gated calcium channels in cortical neurons.

Gabapentin - CAS 60142-96-3 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: L-type Voltage Gated Ca2+ Channel Blocke, Gabapentin

Primary Target: α2δ subunit of L-type voltage gated Ca2+ channels
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508506
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Tableau de caractéristiques principal

CAS #Empirical Formula
60142-96-3C₉H₁₇NO₂

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      Description
      OverviewA water soluble GABA analog originally developed to treat epilepsy and neuropathic pain but is not believed to act on the same brain receptors. Gabapentin interacts with voltage-gated calcium channels in cortical neurons. It binds to the α2δ subunit (1 and 2) and has been found to reduce calcium currents after chronic but not acute application via an effect on trafficking of voltage-dependent calcium channels in the central nervous system.
      Catalogue Number508506
      Brand Family Calbiochem®
      SynonymsL-type Voltage Gated Ca2+ Channel Blocke, Gabapentin
      References
      ReferencesEroglu, C. et al. 2009. Cell. 139, 380.
      Hendrich, J. et al. 2008. Proc. Natl. Acad. Sci. USA 105, 3628.
      Davies, A. et al. 2007. Trends Pharmacol. Sci. 28, 220.
      Product Information
      CAS number60142-96-3
      FormWhite solid
      Hill FormulaC₉H₁₇NO₂
      Chemical formulaC₉H₁₇NO₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetα2δ subunit of L-type voltage gated Ca2+ channels
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      5.08506.0001 04055977261998

      Documentation

      Gabapentin - CAS 60142-96-3 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Eroglu, C. et al. 2009. Cell. 139, 380.
      Hendrich, J. et al. 2008. Proc. Natl. Acad. Sci. USA 105, 3628.
      Davies, A. et al. 2007. Trends Pharmacol. Sci. 28, 220.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-January-2014 JSW
      SynonymsL-type Voltage Gated Ca2+ Channel Blocke, Gabapentin
      DescriptionA water soluble GABA analog originally developed to treat epilepsy and neuropathic pain but is not believed to act on the same brain receptors. Gabapentin interacts with voltage-gated calcium channels in cortical neurons. It binds to the α2δ subunit (1 and 2) and has been found to reduce calcium currents after chronic but not acute application via an effect on trafficking of voltage-dependent calcium channels in the central nervous system.
      FormWhite solid
      CAS number60142-96-3
      Chemical formulaC₉H₁₇NO₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (100 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesEroglu, C. et al. 2009. Cell. 139, 380.
      Hendrich, J. et al. 2008. Proc. Natl. Acad. Sci. USA 105, 3628.
      Davies, A. et al. 2007. Trends Pharmacol. Sci. 28, 220.