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371709 GPR109b Agonist - CAS 306935-41-1 - Calbiochem

The GPR109b Agonist, also referenced under CAS 306935-41-1, controls the biological activity of GPR109b. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 1-(iso-Propyl)-1H-benzotriazole-5-carboxylic acid

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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      306935-41-1C₁₀H₁₁N₃O₂
      Description
      OverviewA cell-permeable Niacin (Cat. No. 481918) triazolo derivative that acts as a potent and selective agonist toward the human orphan G-protein-coupled receptor GPR109b/HM74, but not GPR109a/HM74A or β-adrenergic receptor. Effectively inhibits cAMP elevation induced by forskolin (5 µM, Cat. No. 344270) and isoproterenol (1 µM, Cat. No. 420355), respectively, in GPR109b-expressing CHO cells (EC50 = 400 nM) and freshly isolated human adipocytes (EC50 about 1 µM).
      Catalogue Number371709
      Brand Family Calbiochem®
      Synonyms1-(iso-Propyl)-1H-benzotriazole-5-carboxylic acid
      References
      ReferencesSemple, G., et al. 2006. J. Med. Chem. 49, 1227.
      Product Information
      CAS number306935-41-1
      FormLight brown solid
      Hill FormulaC₁₀H₁₁N₃O₂
      Chemical formulaC₁₀H₁₁N₃O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      371709 0

      Documentation

      GPR109b Agonist - CAS 306935-41-1 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      GPR109b Agonist - CAS 306935-41-1 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      371709

      Références bibliographiques

      Aperçu de la référence bibliographique
      Semple, G., et al. 2006. J. Med. Chem. 49, 1227.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-March-2009 RFH
      Synonyms1-(iso-Propyl)-1H-benzotriazole-5-carboxylic acid
      DescriptionA cell-permeable Niacin (Cat. No. 481918) triazolo derivative that acts as a potent and selective agonist toward the human orphan G-protein-coupled receptor GPR109b/HM74, but not GPR109a/HM74A or β-adrenergic receptor. Effectively inhibits cAMP elevation induced by forskolin (5 µM, Cat. No. 344270) and isoproterenol (1 µM, Cat. No. 420355), respectively, in GPR109b-expressing CHO cells (EC50 = 400 nM) and freshly isolated human adipocytes (EC50 about 1 µM).
      FormLight brown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number306935-41-1
      Chemical formulaC₁₀H₁₁N₃O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml) or Ethanol (2 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesSemple, G., et al. 2006. J. Med. Chem. 49, 1227.