371818 Sigma-AldrichG-Protein βγ Binding Peptide, mSIRK - Calbiochem
A cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes the α subunit dissociation without stimulating nucleotide
More>> A cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes the α subunit dissociation without stimulating nucleotide exchange. Less<<FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: mSIRK, myr-SIRKALNILGYPDYD-OH
Produits recommandés
Aperçu
Tableau de caractéristiques principal
| Empirical Formula |
|---|
| C₉₃H₁₅₀N₂₀O₂₅ |
Prix & Disponibilité
| Référence | Disponibilité | Conditionnement | Qté | Prix | Quantité | |
|---|---|---|---|---|---|---|
| 371818-1MG |
|
Flacon en verre | 1 mg |
|
— | |
| 371818-5MG |
|
Flacon en verre | 5 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes the α subunit dissociation without stimulating nucleotide exchange. Shown to cause a rapid activation of ERK1/2 (EC50 ~ 2.5 - 5 µM) in rat arterial smooth muscle and Rat2 cells. Also promotes the phosphorylation of JNK and p38 MAP kinase, phospholipase C and causes Ca2+ release from internal stores. Negative control is also available (Cat. No. 371820). |
| Catalogue Number | 371818 |
| Brand Family | Calbiochem® |
| Synonyms | mSIRK, myr-SIRKALNILGYPDYD-OH |
| References | |
|---|---|
| References | Goubaeva, F., et al. 2003. J. Biol. Chem. 278, 19634. Scott, J.K., et al. 2001. EMBO J. 20, 767. |
| Product Information | |
|---|---|
| ATP Competitive | N |
| Form | Lyophilized |
| Formulation | Supplied as a trifluoroacetate salt. |
| Hill Formula | C₉₃H₁₅₀N₂₀O₂₅ |
| Chemical formula | C₉₃H₁₅₀N₂₀O₂₅ |
| Hygroscopic | Hygroscopic |
| Reversible | N |
| Quality Level | MQ100 |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Peptide Sequence | Myr-N-Ser-Ile-Arg-Lys-Ala-Leu-Asn-Ile-Leu-Gly-Tyr-Pro-Asp-Tyr-Asp-OH |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Référence | GTIN |
| 371818-1MG | 04055977213423 |
| 371818-5MG | 04055977213430 |