Millipore Sigma Vibrant Logo

508048 Filastatin - Calbiochem

508048
  
Prix en cours de récupération
Le prix n'a pas pu être récupéré
La quantité minimale doit être un multiple de
Maximum Quantity is
À la validation de la commande Plus d'informations
Vous avez sauvegardé ()
 
Demander le prix
Disponibilité limitée
Disponibilité limitée
En stock 
Interrompu(e)
Disponible en quantités limitées
Disponibilité à confirmer
    Pour le restant : Nous vous tiendrons informé
      Pour le restant : Nous vous tiendrons informé
      Nous vous tiendrons informé
      Contacter le Service Clients
      Contact Customer Service

       

      Contacter le Service Clients

      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical Formula
      C₁₈H₁₈ClN₃O₃
      Description
      OverviewA cell-permeable, nontoxic benzoyl-nitrophenylpiperazine compound with anti-fungal properties. Prevents the adhesion of multiple pathogenic Candida species to polystyrene surfaces and human cells (IC50 = 3 µM in A549 cells). Does not affect the viability of human cells even at high concentrations (~250 µM). Also effective, but to slightly lower extent, when added to cells following their adhesion. Keeps cells dispersed in the media and blocks the formation of hyphae (~2.5 µM). Also reported to block the transcriptional induction of the HWP1 promoter and is believed to act downstream of Efg1 transcription factor. Exhibits antifungal activity in a nematode model (C. elegans) and increases the life span of Candida infected worms. Also reported to alter biofilm morphology in a murine model of vulvovaginal candidiasis.
      Catalogue Number508048
      Brand Family Calbiochem®
      Synonyms1-(3-Chloro-4-methylbenzoyl)-4-(4-nitrophenyl)piperazine, (3-Chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone
      References
      ReferencesFazly, A., et al. 2013. Proc. Natl. Acad. Sci. USA 110, 13594.
      Product Information
      FormYellow powder
      Hill FormulaC₁₈H₁₈ClN₃O₃
      Chemical formulaC₁₈H₁₈ClN₃O₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      508048 0

      Documentation

      Filastatin - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Fazly, A., et al. 2013. Proc. Natl. Acad. Sci. USA 110, 13594.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-November-2013 JSW
      Synonyms1-(3-Chloro-4-methylbenzoyl)-4-(4-nitrophenyl)piperazine, (3-Chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone
      DescriptionA cell-permeable, nontoxic benzoyl-nitrophenylpiperazine compound with anti-fungal properties. Prevents the adhesion of multiple pathogenic Candida species to polystyrene surfaces and human cells (IC50 = 3 µM in A549 cells). Does not affect the viability of human cells even at high concentrations (~250 µM). Also effective, but to slightly lower extent, when added to cells following their adhesion. Keeps cells dispersed in the media and blocks the formation of hyphae (~2.5 µM). Also reported to block the transcriptional induction of the HWP1 promoter and is believed to act downstream of Efg1 transcription factor. Exhibits antifungal activity in a nematode model (C. elegans) and increases the life span of Candida infected worms. Also reported to alter biofilm morphology in a murine model of vulvovaginal candidiasis.
      FormYellow powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₈H₁₈ClN₃O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesFazly, A., et al. 2013. Proc. Natl. Acad. Sci. USA 110, 13594.