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341608 FGF Receptor Tyrosine Kinase Inhibitor - CAS 192705-79-6 - Calbiochem

The FGF Receptor Tyrosine Kinase Inhibitor, also referenced under CAS 192705-79-6, controls the biological activity of FGF Receptor Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: PD 166866, 1-(2-Amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea

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341608
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Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
192705-79-6C₂₀H₂₄N₆O₃

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341608-5MG
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      Description
      OverviewA cell-permeable pyridopyrimidinyl urea compound that acts a potent, ATP-competitive inhibitor of FGFR (IC50 = 60 nM using FGFR1) with excellent selectivity over PDGFRβ, EGFR, insulin receptor, and c-Src (IC50 > 50 µM).
      Catalogue Number341608
      Brand Family Calbiochem®
      SynonymsPD 166866, 1-(2-Amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea
      References
      ReferencesPanek, R.L., et al. 1998. J. Pharm. Exp. Ther. 286, 569.
      Hamby, J.M., et al. 1997. J. Med. Chem. 40, 2296.
      Product Information
      CAS number192705-79-6
      FormOff-white solid
      Hill FormulaC₂₀H₂₄N₆O₃
      Chemical formulaC₂₀H₂₄N₆O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      341608-5MG 04055977195217

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      FGF Receptor Tyrosine Kinase Inhibitor - CAS 192705-79-6 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      FGF Receptor Tyrosine Kinase Inhibitor - CAS 192705-79-6 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      341608

      Références bibliographiques

      Aperçu de la référence bibliographique
      Panek, R.L., et al. 1998. J. Pharm. Exp. Ther. 286, 569.
      Hamby, J.M., et al. 1997. J. Med. Chem. 40, 2296.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-April-2011 RFH
      SynonymsPD 166866, 1-(2-Amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea
      DescriptionA cell-permeable pyridopyrimidinyl urea compound that acts a potent, ATP-competitive inhibitor of FGFR (IC50 = 60 nM using FGFR1) with excellent selectivity over PDGFRβ, EGFR, insulin receptor, and c-Src (IC50 > 50 µM).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number192705-79-6
      Chemical formulaC₂₀H₂₄N₆O₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesPanek, R.L., et al. 1998. J. Pharm. Exp. Ther. 286, 569.
      Hamby, J.M., et al. 1997. J. Med. Chem. 40, 2296.