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14-673M EphA8 Protein, active, 250 µg

Active, N-terminal 6His-tagged, recombinant, human EphA8 residues 615-911, for use in Kinase Assays.

14-673M
250 µg  Also available in 10 μg size (cat#14-673) and in bulk (cat#14-673-K).
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      Aperçu

      Replacement Information
      Description
      Catalogue Number14-673M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionEphA8 Protein, active, 250 µg
      OverviewN-terminal 6His-tagged, recombinant, human EphA8 residues 615-911
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationActive, N-terminal 6His-tagged, recombinant, human EphA8 residues 615-911, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourceexpressed by baculovirus in Sf21 cells
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system.
      Gene Symbol
      • EPHA8
      • HEK3
      • KIAA1459
      • EphA8
      • EEK
      • Hek3
      Protein TargetEphA8
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyTK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P29322 # Receptor for members of the ephrin-A family.
      SIZE: 1005 amino acids; 111003 Da
      SUBUNIT: Interacts with FYN (By similarity).
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      PTM: Phosphorylation on Tyr-616 is critical for association with FYN (By similarity). & Phosphorylation on Tyr-839 modulates tyrosine kinase activity (By similarity).
      SIMILARITY: SwissProt: P29322 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. & Contains 2 fibronectin type-III domains. & Contains 1 protein kinase domain. & Contains 1 SAM (sterile alpha motif) domain.
      Molecular Weight37.1 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of PDKtide (Catalog # 12-401)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C from date of shipment
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-673) and in bulk (cat#14-673-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      14-673M 04053252924927

      Documentation

      Produits & Applications associés

      Alternative Packsize

      Référence Description  
      14-673 EphA8 Protein, active, 10 µg Prix & Disponibilité

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      Catégories

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases