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324760 Endothall - CAS 145-73-3 - Calbiochem

Endothall - CAS 145-73-3 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic Acid

Primary Target: PP2A
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      145-73-3C₈H₁₀O₅
      Description
      Overview

      This product has been discontinued.



      A cell-permeable, specific inhibitor of protein phosphatase 2A (PP2A, IC50 = 90 nM). Exhibits only a weak effect on PP1 (IC50 = 5 µM). Causes dose- and time-dependent cytostasis at the G2/M phase in hepatocellular carcinoma cell lines.
      Catalogue Number324760
      Brand Family Calbiochem®
      Synonyms7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic Acid
      References
      ReferencesAyaydin, F., et al. 2000. Plant J. 23, 85.
      Thiery, J.P., et al. 1999. Hepatology 29, 1406.
      Li, Y.M., et al. 1993. Biochem. Pharmacol. 46, 1435.
      Li, Y.M., and Casida, J.E. 1992. Proc. Natl. Acad. Sci. USA 89, 11867.
      Product Information
      CAS number145-73-3
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₈H₁₀O₅
      Chemical formulaC₈H₁₀O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPP2A
      Primary Target IC<sub>50</sub>90 nM against protein phosphatase 2A (PP2A)
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSRN7875000
      Safety Information
      R PhraseR: 21-25-36/37/38

      Harmful in contact with skin.
      Toxic if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 36/37/39-45

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      324760 0

      Documentation

      Endothall - CAS 145-73-3 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Endothall - CAS 145-73-3 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      324760

      Références bibliographiques

      Aperçu de la référence bibliographique
      Ayaydin, F., et al. 2000. Plant J. 23, 85.
      Thiery, J.P., et al. 1999. Hepatology 29, 1406.
      Li, Y.M., et al. 1993. Biochem. Pharmacol. 46, 1435.
      Li, Y.M., and Casida, J.E. 1992. Proc. Natl. Acad. Sci. USA 89, 11867.

      Brochure

      Titre
      Protein Phosphatases Technical Bulletin
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-June-2008 RFH
      Synonyms7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic Acid
      DescriptionA specific, cell-permeable inhibitor of protein phosphatase 2A (PP2A)(IC50 = 90 nM). Exhibits only weak inhibitory activity towards protein phosphatase 1 (PP1) (IC50 = 5 µM). Causes dose- and time-dependent cytostasis at the G2/M phase in hepatocellular carcinoma cell lines.
      FormWhite solid
      CAS number145-73-3
      RTECSRN7875000
      Chemical formulaC₈H₁₀O₅
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityH₂O (25 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Toxic
      ReferencesAyaydin, F., et al. 2000. Plant J. 23, 85.
      Thiery, J.P., et al. 1999. Hepatology 29, 1406.
      Li, Y.M., et al. 1993. Biochem. Pharmacol. 46, 1435.
      Li, Y.M., and Casida, J.E. 1992. Proc. Natl. Acad. Sci. USA 89, 11867.