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324410 Dynamin Inhibitor I, Dynasore - CAS 304448-55-3 - Calbiochem

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Tableau de caractéristiques principal

CAS #Empirical Formula
304448-55-3C₁₈H₁₄N₂O₄

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324410-10MG
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      Description
      OverviewA cell-permeable semicarbazone compound that inhibits the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1, while exhibiting no significant effect against two other small GTPases, MxA and Cdc42. Dynasore has been used to elucidate the roles of dynamin in endocytosis mediated by both clathrin-coated and synaptic vesicles. The inhibitition is noncompetitive with respect to GTP and the inhibitor target site presumably resides in the GTPase domain. Shown to inhibit removal of both wt and ΔF508-CFTR from the plasma membrane.
      Catalogue Number324410
      Brand Family Calbiochem®
      Synonyms3-Hydroxynaphthalene-2-carboxylic acid-(3,4-dihydroxybenzylidene)-hydrazide, Sore to Dynamin
      References
      ReferencesYoung, A., et al. 2009. Biochem. J. , In press.
      Nankoe, S.R., and Sever, S. 2006. Trends Cell Biol. 16, 607.
      Newton, A.J., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 17955.
      Macia. E., et al. 2006. Dev. Cell 10, 839.
      Product Information
      CAS number304448-55-3
      FormPale yellow solid
      Hill FormulaC₁₈H₁₄N₂O₄
      Chemical formulaC₁₈H₁₄N₂O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationDynamin Inhibitor I, Dynasore, CAS 304448-55-3, is a cell-permeable inhibitor of the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1. Has no significant effect on MxA and Cdc42.
      Biological Information
      Purity≥98% by HPLC
      Safety Information
      R PhraseR: 50

      Very toxic to aquatic organisms.
      S PhraseS: 22-24/25

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Environmental Hazard
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Référence GTIN
      324410-10MG 04055977197167