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324377 Donepezil Hydrochloride - Calbiochem

A brain-penetrating, reversible, and selective piperidine acetylcholinesterase inhibitor with an IC₅₀ = 5.7 nM in vitro, and a 1250-fold selectivity over butylcholinesterase.

Donepezil Hydrochloride - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: E2020, (R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]-methylpiperidine hydrochloride

324377
  
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical Formula
      C₂₄H₂₉NO₃HCl
      Description
      Overview

      This product has been discontinued.



      A brain-penetrating, reversible, and selective piperidine acetylcholinesterase inhibitor with an IC50 = 5.7 nM in vitro, and a 1250-fold selectivity over butylcholinesterase. In vivo, there is a marked and significant increase in acetylcholine content in rat cerebral cortex at a p.o. dose of 5 mg/kg. Furthermore, it inhibits brain cholinesterase (ChE) dose-dependently (ID50 = 2.6 mg/kg) without any marked adverse effects on ChE in the heart and small intestine. In a clinical trial, it has been shown to reduce AChE activity by 63.7% for the 5mg/d group and 77.3% for the 10mg/d group in Alzheimer's disease patients. Its off-target effects are indicated with the reversibly of inhibited voltage-gated K+/Na+ channels.
      Catalogue Number324377
      Brand Family Calbiochem®
      SynonymsE2020, (R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]-methylpiperidine hydrochloride
      References
      ReferencesYu, B., et al. 2005. Eur J Pharm 508, 15.
      Ogura, H., et al. 2000. Nippon Yakurigaky Zasshi 115, 45.
      Sugimoto, H., et al. 1995. J Med Chem 38, 4821.
      Rogers, S., et al. 1998. Neurology 50, 136.
      Product Information
      FormWhite solid
      Hill FormulaC₂₄H₂₉NO₃HCl
      Chemical formulaC₂₄H₂₉NO₃HCl
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      324377 0

      Documentation

      Donepezil Hydrochloride - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Donepezil Hydrochloride - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      324377

      Références bibliographiques

      Aperçu de la référence bibliographique
      Yu, B., et al. 2005. Eur J Pharm 508, 15.
      Ogura, H., et al. 2000. Nippon Yakurigaky Zasshi 115, 45.
      Sugimoto, H., et al. 1995. J Med Chem 38, 4821.
      Rogers, S., et al. 1998. Neurology 50, 136.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-November-2011 RFH
      SynonymsE2020, (R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]-methylpiperidine hydrochloride
      DescriptionA brain-penetrating, reversible, and selective piperidine acetylcholinesterase inhibitor with an IC50 = 5.7 nM in vitro, and a 1250-fold selectivity over butylcholinesterase. In vivo, there is a marked and significant increase in acetylcholine content in rat cerebral cortex at a p.o. dose of 5 mg/kg. Furthermore, it inhibits brain cholinesterase (ChE) dose-dependently (ID50 = 2.6 mg/kg) without any marked adverse effects on ChE in the heart and small intestine. In a clinical trial, it has been shown to reduce AChE activity by 63.7% for the 5mg/d group and 77.3% for the 10mg/d group in Alzheimer's disease patients. Its off-target effects are indicated with the reversibly of inhibited voltage-gated K+/Na+ channels.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₄H₂₉NO₃HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (16 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesYu, B., et al. 2005. Eur J Pharm 508, 15.
      Ogura, H., et al. 2000. Nippon Yakurigaky Zasshi 115, 45.
      Sugimoto, H., et al. 1995. J Med Chem 38, 4821.
      Rogers, S., et al. 1998. Neurology 50, 136.