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266785 Diacylglycerol Kinase Inhibitor I - CAS 93076-89-2 - Calbiochem

The Diacylglycerol Kinase Inhibitor I, also referenced under CAS 93076-89-2, controls the biological activity of Diacylglycerol Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: R59022, 6-{2-{4-[(p-Fluorophenyl)phenylmethylene]-1-piperidinyl}ethyl}-7-methyl-5H-thiazolo(3,2-a)pyrimidine-5-one

Primary Target: Diacylglycerol Kinase
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266785
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Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
93076-89-2C₂₇H₂₆FN₃OS

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266785-5MG
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      Description
      OverviewPotentiates the activity of protein kinase C by inhibiting diacylglycerol metabolism. Inhibits diacylglycerol kinase (IC50 = 2.8 µM) without affecting phosphodiesterase or phosphatidylinositol kinase. Weak dopamine D2 and histamine H1 antagonist and strong serotonin S2 antagonist.
      Catalogue Number266785
      Brand Family Calbiochem®
      SynonymsR59022, 6-{2-{4-[(p-Fluorophenyl)phenylmethylene]-1-piperidinyl}ethyl}-7-methyl-5H-thiazolo(3,2-a)pyrimidine-5-one
      References
      ReferencesGoin, M., et al. 1993. FEBS Lett. 316, 68.
      Ohtsuka, T., et al. 1990. J. Biol. Chem. 265, 15418.
      de Chaffoy de Courcelles, D., et al. 1985. J. Biol. Chem. 260, 15762.
      Product Information
      CAS number93076-89-2
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₇H₂₆FN₃OS
      Chemical formulaC₂₇H₂₆FN₃OS
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetDiacylglycerol Kinase
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      266785-5MG 04055977197761

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Diacylglycerol Kinase Inhibitor I - CAS 93076-89-2 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Diacylglycerol Kinase Inhibitor I - CAS 93076-89-2 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      266785

      Références bibliographiques

      Aperçu de la référence bibliographique
      Goin, M., et al. 1993. FEBS Lett. 316, 68.
      Ohtsuka, T., et al. 1990. J. Biol. Chem. 265, 15418.
      de Chaffoy de Courcelles, D., et al. 1985. J. Biol. Chem. 260, 15762.

      Citations

      Titre
    • Fernando C. Gómez-Merino, et al. (2005) Arabidopsis AtDGK7, the smallest member of plant diacylglycerol kinases, displays unique biochemical features and saturates at low substrate concentration-the DGK inhibitor R59022 differentially affects AtDGK2 and AtDGK7 activity in vitro, and alters plan. Journal of Biological Chemistry 280, 34888-34899.
      		•
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-June-2008 RFH
      SynonymsR59022, 6-{2-{4-[(p-Fluorophenyl)phenylmethylene]-1-piperidinyl}ethyl}-7-methyl-5H-thiazolo(3,2-a)pyrimidine-5-one
      DescriptionPotentiates the activity of protein kinase C by inhibiting diacylglycerol metabolism. Inhibits diacylglycerol kinase (IC50 = 2.8 µM) without affecting phosphodiesterase or phosphatidylinositol kinase. Potentiates this effect in studies of signal-transducing inositol lipid metabolism. Inhibits human platelet DAG kinase in intact cells (IC50 = 3.6 µM) and in isolated membranes (IC50 = 6.7 µM). In porcine thymus cytosol it inhibits the 80 kDa DAG kinase (IC50 = 10 µM) but has no effect on the 150 kDa DAG kinase. Weak dopamine D2 and histamine H1 antagonist and strong serotonin-S2 antagonist.
      FormWhite solid
      CAS number93076-89-2
      Chemical formulaC₂₇H₂₆FN₃OS
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (4 mg/ml) or Ethanol (12 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.
      Toxicity Irritant
      ReferencesGoin, M., et al. 1993. FEBS Lett. 316, 68.
      Ohtsuka, T., et al. 1990. J. Biol. Chem. 265, 15418.
      de Chaffoy de Courcelles, D., et al. 1985. J. Biol. Chem. 260, 15762.
      Citation
    • Fernando C. Gómez-Merino, et al. (2005) Arabidopsis AtDGK7, the smallest member of plant diacylglycerol kinases, displays unique biochemical features and saturates at low substrate concentration-the DGK inhibitor R59022 differentially affects AtDGK2 and AtDGK7 activity in vitro, and alters plan. Journal of Biological Chemistry 280, 34888-34899.
      		•