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219478 Cdk4 Inhibitor III - CAS 265312-55-8 - Calbiochem

The Cdk4 Inhibitor III, also referenced under CAS 265312-55-8, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 5-(N-(4-Methylphenyl)amino)-2-methyl-4,7-dioxobenzothiazole, Ryuvidine

Primary Target: Cdk4
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219478
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
265312-55-8C₁₅H₁₂N₂O₂S

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219478-5MG
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      Description
      OverviewA cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor (IC50 = 6.0 µM for Cdk4/D1 and > 200 µM for Cdk2/A). Exhibit better cytotoxic potential against cancer cells (IC50 = 0.61, 1.08, 0.30, and 1.21 µg/ml against A 549, Col 1, HL-60, and HepG2 tumor cells, respectively) than Cisplatin (Cat. No. 232120).
      Catalogue Number219478
      Brand Family Calbiochem®
      Synonyms5-(N-(4-Methylphenyl)amino)-2-methyl-4,7-dioxobenzothiazole, Ryuvidine
      References
      ReferencesRyu, C.K., et al. 2000. Bioorg. Med. Chem. Lett. 10, 461.
      Product Information
      CAS number265312-55-8
      ATP CompetitiveN
      FormBlack-purple solid
      Hill FormulaC₁₅H₁₂N₂O₂S
      Chemical formulaC₁₅H₁₂N₂O₂S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCdk4
      Primary Target IC<sub>50</sub>6.0 µM for Cdk4/D1 and > 200 µM for Cdk2/A
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      219478-5MG 04055977218558

      Documentation

      Cdk4 Inhibitor III - CAS 265312-55-8 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Cdk4 Inhibitor III - CAS 265312-55-8 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      219478

      Références bibliographiques

      Aperçu de la référence bibliographique
      Ryu, C.K., et al. 2000. Bioorg. Med. Chem. Lett. 10, 461.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-October-2013 JSW
      Synonyms5-(N-(4-Methylphenyl)amino)-2-methyl-4,7-dioxobenzothiazole, Ryuvidine
      DescriptionA cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor (IC50 = 6.0 µM for Cdk4/D1 and >200 µM for Cdk2/A). Exhibit better cytotoxic potential against cancer cells (IC50 = 0.61, 1.08, 0.30, and 1.21 µg/ml against A 549, Col 1, HL-60, and HepG2 tumor cells, respectively) than Cisplatin (Cat. No. 232120).
      FormBlack-purple solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number265312-55-8
      Chemical formulaC₁₅H₁₂N₂O₂S
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesRyu, C.K., et al. 2000. Bioorg. Med. Chem. Lett. 10, 461.