219457 Sigma-AldrichCdk Inhibitor, p35 - CAS 471270-60-7 - Calbiochem
More>>
Less<<
Primary Target:
CDK1, CDK2
FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: 2-(3-Hydroxypropylamino)-6-(o-hydroxybenzylamino)-9-isopropylpurine
Produits recommandés
Aperçu
Tableau de caractéristiques principal
| CAS # | Empirical Formula |
|---|---|
| 471270-60-7 | C₁₈H₂₄N₆O₂ |
| Description | |
|---|---|
| Overview | This product has been discontinued. An analog of Olomoucine (Cat. No. 495620) that acts as a potent inhibitor of Cdk1 (IC50 = 100 nM) and Cdk2 (IC50 = 80 nM). Also displays anti-proliferative and pro-apoptotic effects. The correlation between inhibition of Cdk1/Cdk2 and inhibition of cell proliferation suggests that the anti-proliferative effects are due, in part, to Cdk inhibition. |
| Catalogue Number | 219457 |
| Brand Family | Calbiochem® |
| Synonyms | 2-(3-Hydroxypropylamino)-6-(o-hydroxybenzylamino)-9-isopropylpurine |
| References | |
|---|---|
| References | Vermeulen, K., et al. 2002. Leukemia 16, 299. |
| Product Information | |
|---|---|
| CAS number | 471270-60-7 |
| ATP Competitive | N |
| Form | Yellow solid |
| Hill Formula | C₁₈H₂₄N₆O₂ |
| Chemical formula | C₁₈H₂₄N₆O₂ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | CDK1, CDK2 |
| Primary Target IC<sub>50</sub> | 100 nM, 80 nM, against Cdk1 and Cdk2, respectively |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | N |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Référence | GTIN |
| 219457 | 0 |